Bioactive and other sesquiterpenoids from Porella cordeana

G. G. Harrigan, A. Ahmad, N. Baj, T. E. Glass, A. A.L. Gunatilaka, D. G.I. Kingston

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Bioassay-directed fractionation of the MeCOEt extract of Porella cordeana yielded drimenin [1] and aristolone [4], which were moderately toxic towards DNA-repairdeficient mutants of Saccharomyces cerevisiae. Three inactive sesquiterpenes, 7-ketoisodrimenin [2], 7-ketoisodrimenin-5-ene [3], and norpinguisanolide, were also obtained. Compounds 2 and 3 are new.

Original languageEnglish (US)
Pages (from-to)921-925
Number of pages5
JournalJournal Of Natural Products
Volume56
Issue number6
DOIs
StatePublished - Jun 1993
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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