Bioactive ergost-5-ene-3β, 7α-diol derivatives from Pseudobersama mossambicensis

Leslie Gunatilaka, Gamini Samaranayake, David G I Kingston, Glenn Hoffmann, Randall K. Johnson

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Bioactivity-directed fractionation of the methyl ethyl ketone extract of Pseudobersama mossambicensis resulted in the isolation of ergosta-5,24(28)-diene-3β,7α-diol [1], 24,28-epoxyergost-5-ene-3β,7α-diol [2], and ergost-5-ene-3β,7α,24,28-tetraol [3]. All three sterols showed selective activity towards DNA repair-deficient yeast mutants. The sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells. The isolation, structural elucidation, and biological activities of these sterols are reported. The sterol 3 is most probably an artifact formed from 2 during the isolation process.

Original languageEnglish (US)
Pages (from-to)1648-1654
Number of pages7
JournalJournal of Natural Products
Volume55
Issue number11
StatePublished - 1992
Externally publishedYes

Fingerprint

glycols
Sterols
sterols
chemical derivatives
Derivatives
Bioactivity
DNA Repair-Deficiency Disorders
Cytotoxicity
Fractionation
DNA repair
ketones
leukemia
Yeast
Artifacts
cytotoxicity
bioactive properties
fractionation
Leukemia
Repair
Yeasts

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Gunatilaka, L., Samaranayake, G., Kingston, D. G. I., Hoffmann, G., & Johnson, R. K. (1992). Bioactive ergost-5-ene-3β, 7α-diol derivatives from Pseudobersama mossambicensis. Journal of Natural Products, 55(11), 1648-1654.

Bioactive ergost-5-ene-3β, 7α-diol derivatives from Pseudobersama mossambicensis. / Gunatilaka, Leslie; Samaranayake, Gamini; Kingston, David G I; Hoffmann, Glenn; Johnson, Randall K.

In: Journal of Natural Products, Vol. 55, No. 11, 1992, p. 1648-1654.

Research output: Contribution to journalArticle

Gunatilaka, L, Samaranayake, G, Kingston, DGI, Hoffmann, G & Johnson, RK 1992, 'Bioactive ergost-5-ene-3β, 7α-diol derivatives from Pseudobersama mossambicensis', Journal of Natural Products, vol. 55, no. 11, pp. 1648-1654.
Gunatilaka L, Samaranayake G, Kingston DGI, Hoffmann G, Johnson RK. Bioactive ergost-5-ene-3β, 7α-diol derivatives from Pseudobersama mossambicensis. Journal of Natural Products. 1992;55(11):1648-1654.
Gunatilaka, Leslie ; Samaranayake, Gamini ; Kingston, David G I ; Hoffmann, Glenn ; Johnson, Randall K. / Bioactive ergost-5-ene-3β, 7α-diol derivatives from Pseudobersama mossambicensis. In: Journal of Natural Products. 1992 ; Vol. 55, No. 11. pp. 1648-1654.
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