Bioactive ergost-5-ene-3β,7α-diol derivatives from pseudobersama mossambicensis

A. A.Leslie Gunatilaka, Gamini Samaranayake, David G.I. Kingston, Glenn Hoffmann, Randall K. Johnson

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Bioactivity-directed fractionation of the methyl ethyl ketone extract of Pseudobersama mossambicensis resulted in the isolation of ergosta-5,24(28)-diene-3β,7α-diol {1}, 24,28-epoxyergost-5-ene-3β,7α-diol {2}, and ergost-5-ene-3β,7α,24,28-tetraol {3}. All three sterols showed selective activity towards DNA repair-deficient yeast mutants. The sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells. The isolation, structural elucidation, and biological activities of these sterols are reported. The sterol 3 is most probably an artifact formed from 2 during the isolation process.

Original languageEnglish (US)
Pages (from-to)1648-1654
Number of pages7
JournalJournal Of Natural Products
Volume55
Issue number11
DOIs
StatePublished - Nov 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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