Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)

Carlos Alberto Carbonezi, Lidilhone Hamerski, A. A.Leslie Gunatilaka, Alberto Cavalheiro, Ian Castro-Gamboa, Dulce Helena Siqueira Silva, Maysa Furlan, Maria Claudia Marx Young, Marcia Nasser Lopes, Vanderlan Da Silva Bolzani

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7′, 4‴-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalRevista Brasileira de Farmacognosia
Volume17
Issue number3
DOIs
StatePublished - 2007

Keywords

  • Antibacterial activity
  • Biflavonoids
  • Ochnaceae
  • Ouratea multiflora

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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