Bioactive guanidine alkaloids from pterogyne nitens

Vanderlan Da S. Bolzani, A. A.Leslie Gunatilaka, David G.I. Kingston

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Bioactivity-guided fractionation of a methanolic CHC13 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC12=93-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B1 cells (IC50=8.5-13.0 μg/ml).

Original languageEnglish (US)
Pages (from-to)1683-1688
Number of pages6
JournalJournal Of Natural Products
Volume58
Issue number11
DOIs
StatePublished - Nov 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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