Bioactive guanidine alkaloids from Pterogyne nitens

Vanderlan Da S Bolzani, Leslie Gunatilaka, David G I Kingston

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of a methanolic CHCl3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B1 cells (IC50=8.5-13.0 μg/ml).

Original languageEnglish (US)
Pages (from-to)1683-1688
Number of pages6
JournalJournal of Natural Products
Volume58
Issue number11
StatePublished - 1995
Externally publishedYes

Fingerprint

Pterogyne
guanidines
Guanidine
Alkaloids
alkaloids
DNA Repair-Deficiency Disorders
Fractionation
DNA repair
Bioactivity
leaf extracts
Yeast
Inhibitory Concentration 50
inhibitory concentration 50
fractionation
Repair
Yeasts
yeasts
mutants
DNA
cells

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Bolzani, V. D. S., Gunatilaka, L., & Kingston, D. G. I. (1995). Bioactive guanidine alkaloids from Pterogyne nitens. Journal of Natural Products, 58(11), 1683-1688.

Bioactive guanidine alkaloids from Pterogyne nitens. / Bolzani, Vanderlan Da S; Gunatilaka, Leslie; Kingston, David G I.

In: Journal of Natural Products, Vol. 58, No. 11, 1995, p. 1683-1688.

Research output: Contribution to journalArticle

Bolzani, VDS, Gunatilaka, L & Kingston, DGI 1995, 'Bioactive guanidine alkaloids from Pterogyne nitens', Journal of Natural Products, vol. 58, no. 11, pp. 1683-1688.
Bolzani, Vanderlan Da S ; Gunatilaka, Leslie ; Kingston, David G I. / Bioactive guanidine alkaloids from Pterogyne nitens. In: Journal of Natural Products. 1995 ; Vol. 58, No. 11. pp. 1683-1688.
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