Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors

Michael D. Pluth, Elisa Tomat, Stephen J. Lippard

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Biological mobile zinc and nitric oxide (NO) are two prominent examples of inorganic compounds involved in numerous signaling pathways in living systems. In the past decade, a synergy of regulation, signaling, and translocation of these two species has emerged in several areas of human physiology, providing additional incentive for developing adequate detection systems for Zn(II) ions and NO in biological specimens. Fluorescent probes for both of these bioinorganic analytes provide excellent tools for their detection, with high spatial and temporal resolution. We review the most widely used fluorescent sensors for biological zinc and nitric oxide, together with promising new developments and unmet needs of contemporary Zn(II) and NO biological imaging. The interplay between zinc and nitric oxide in the nervous, cardiovascular, and immune systems is highlighted to illustrate the contributions of selective fluorescent probes to the study of these two important bioinorganic analytes.

Original languageEnglish (US)
Pages (from-to)333-355
Number of pages23
JournalAnnual Review of Biochemistry
Volume80
DOIs
StatePublished - Jul 7 2011
Externally publishedYes

Fingerprint

Zinc Oxide
Biochemistry
Nitric Oxide
Sensors
Fluorescent Dyes
Inorganic compounds
Cardiovascular system
Immune system
Physiology
Neurology
Cardiovascular System
Nervous System
Motivation
Immune System
Ions
Imaging techniques

Keywords

  • cell imaging
  • fluorescent probes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors. / Pluth, Michael D.; Tomat, Elisa; Lippard, Stephen J.

In: Annual Review of Biochemistry, Vol. 80, 07.07.2011, p. 333-355.

Research output: Contribution to journalArticle

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