Biocompatible electrospun titania-composite nanofiber networks for whole cell sensing

Jamie M.F. Jabal, Anjil Giri, Kurt E. Gustin, D. Eric Aston

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biosensor technology includes the detection of generated biological functionality. One whole-cell biosensor concept leaves specific receptor molecules in their natural environment to be optimized and adapted for efficient molecular recognition during evolution, and to use intact cells as biologically-active elements. In this project, a basic nanomaterials platform for whole cell sensors is produced by electrospinning composite nano- and microfiber networks. The resulting polymer-metal oxide (titania) "nano-mats" are fabricated on a conductive indium tin oxide (ITO) coated glass substrate for epithelial or other cell incubation and future incorporation into bioelectronics. Impedance spectroscopy is used to characterize cell interactions with the nano-mat to detect changes in cells with proliferation or when exposed to chemical stimuli, such as lactic acid. Cell response to media conditions can include growth, attachment and s preading, motility and migration, and cell death.

Original languageEnglish (US)
Title of host publicationProceedings - 2008 International Symposium on Microelectronics, IMAPS 2008
Pages827-833
Number of pages7
StatePublished - Dec 1 2008
Externally publishedYes
Event41st Annual International Symposium on Microelectronics, IMAPS 2008 - Providence, RI, United States
Duration: Nov 2 2008Nov 6 2008

Publication series

NameProceedings - 2008 International Symposium on Microelectronics, IMAPS 2008

Other

Other41st Annual International Symposium on Microelectronics, IMAPS 2008
CountryUnited States
CityProvidence, RI
Period11/2/0811/6/08

Keywords

  • Biosensor
  • Electrospinning
  • Impedance spectroscopy
  • Indium tin oxide
  • Titania nanofibers
  • Whole-cell sensing

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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  • Cite this

    Jabal, J. M. F., Giri, A., Gustin, K. E., & Aston, D. E. (2008). Biocompatible electrospun titania-composite nanofiber networks for whole cell sensing. In Proceedings - 2008 International Symposium on Microelectronics, IMAPS 2008 (pp. 827-833). (Proceedings - 2008 International Symposium on Microelectronics, IMAPS 2008).