Biodegradable plasmon resonant nanoshells

Timothy S. Troutman, Jennifer K Barton, Marek Romanowski

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

A study has illustrated the preparation and testing of biodegradable plasmon resonant nanoshells of 63 nm diameter formed using shell sprayed array of gold clusters supported on a spherical biodegradable core. The proposed grade of materials maintains optical tunability characteristics of solid metallic shells, and upon degradation yields individual clusters of 5.7 nm diameter, compatible with requirements of renal clearance. The attempt on biodegradable metallic nanoparticles may enable clinical translation of many research stage technologies. The study has prepared degradable plasmon resonant nanostructures, in which liposomes made of dialkyl phosphatidylcholine served as the spherical template, and also developed the composite shell obtained by formation of gold-lipid complexes. Biodegradable plasmon resonant contrast agents may improve clinical OCT images, and can also further enhance in vivo targeting and detection of molecular markers of diagnostic importance.

Original languageEnglish (US)
Pages (from-to)2604-2608
Number of pages5
JournalAdvanced Materials
Volume20
Issue number13
DOIs
StatePublished - Jul 2 2008

Fingerprint

Nanoshells
Gold
Optical materials
Liposomes
Phosphatidylcholines
Lipids
Contrast Media
Nanostructures
Nanoparticles
Degradation
Composite materials
Testing

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Biodegradable plasmon resonant nanoshells. / Troutman, Timothy S.; Barton, Jennifer K; Romanowski, Marek.

In: Advanced Materials, Vol. 20, No. 13, 02.07.2008, p. 2604-2608.

Research output: Contribution to journalArticle

Troutman, Timothy S. ; Barton, Jennifer K ; Romanowski, Marek. / Biodegradable plasmon resonant nanoshells. In: Advanced Materials. 2008 ; Vol. 20, No. 13. pp. 2604-2608.
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