Biodistribution and clearance of liposomal gadolinium-DPTA

Evan C Unger, D. Cardenas, A. Zerella, L. L. Fajardo, C. Tilcock

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Gadolinium-DTPA (Gd-DTPA) liposomes have been studied previously as liver contrast agents and have been shown to improve the detection of hepatic metastases in rats. We synthesized 100-nm and 50-nm liposomes that encapsulated Gd-DTPA and did biodistribution and clearance studies in rats. Parallel magnetic resonance imaging (MRI) studies were also done. Biodistribution showed a prolonged blood pool phase for Gd-DTPA liposomes with a blood pool half-life of approximately 4 hours for the 100-nm liposomes. The highest uptake per gram of tissue was achieved by the spleen. Clearance of gadolinium from the liver and spleen showed a half-life of 3 to 4 days. The smaller 50-nm Gd-DTPA liposomes resulted in a longer blood pool phase and a higher delivery of gadolinium to the liver, bone marrow, and spleen. Imaging studies after intravenous (IV) administration of liposomal Gd-DTPA showed organ enhancement that paralleled the data on biodistribution studies, with appreciable hepatic enhancement at doses as low as 0.025 mm/kg of liposomal Gd-DTPA.

Original languageEnglish (US)
Pages (from-to)638-644
Number of pages7
JournalInvestigative Radiology
Volume25
Issue number6
StatePublished - 1990

Fingerprint

Gadolinium DTPA
Gadolinium
Liposomes
Liver
Spleen
Half-Life
Intravenous Administration
Contrast Media
Bone Marrow
Magnetic Resonance Imaging
Neoplasm Metastasis

Keywords

  • biodistribution
  • clearance
  • gadolinium-DTPA
  • lipsomes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Unger, E. C., Cardenas, D., Zerella, A., Fajardo, L. L., & Tilcock, C. (1990). Biodistribution and clearance of liposomal gadolinium-DPTA. Investigative Radiology, 25(6), 638-644.

Biodistribution and clearance of liposomal gadolinium-DPTA. / Unger, Evan C; Cardenas, D.; Zerella, A.; Fajardo, L. L.; Tilcock, C.

In: Investigative Radiology, Vol. 25, No. 6, 1990, p. 638-644.

Research output: Contribution to journalArticle

Unger, EC, Cardenas, D, Zerella, A, Fajardo, LL & Tilcock, C 1990, 'Biodistribution and clearance of liposomal gadolinium-DPTA', Investigative Radiology, vol. 25, no. 6, pp. 638-644.
Unger EC, Cardenas D, Zerella A, Fajardo LL, Tilcock C. Biodistribution and clearance of liposomal gadolinium-DPTA. Investigative Radiology. 1990;25(6):638-644.
Unger, Evan C ; Cardenas, D. ; Zerella, A. ; Fajardo, L. L. ; Tilcock, C. / Biodistribution and clearance of liposomal gadolinium-DPTA. In: Investigative Radiology. 1990 ; Vol. 25, No. 6. pp. 638-644.
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