Biogenic amines and control of melanophore stimulating hormone release

Annette Bower, Mac E. Hadley, Victor J. Hruby

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

Release of melanophore stimulating hormone (MSH) from the vertebrate pars intermedia is under inhibitory control by the hypothalamus. Removal of the rat pituitary or the neurointermediate lobe of the frog (Rana pipiens) to in vitro incubation medium results in rapid uninhibited release of MSH. This secretion is inhibited by norepinephrine, epinephrine, phenylephrine, and dopamine, and the inhibition is antagonized by α-adrenergic receptor blocking agents. Isoproterenol stimulation of MSH secretion from isolated glands is blocked by propranolol, a β-adrenergic receptor antagonist. These results implicate dopaminergic or classical α-adrenergic receptors (or both) in inhibition of MSH release by catecholamines, and implicate β-adrenergic by the bioamines.

Original languageEnglish (US)
Pages (from-to)70-72
Number of pages3
JournalScience
Volume184
Issue number4132
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • General

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