Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin

Andrzej W. Lipkowski, Aleksandra Misicka, Peg Davis, Dagmar Stropova, Jacqueline Janders, Magdalena Lachwa, Frank Porreca, Henry I. Yamamura, Victor J. Hruby

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The synthesis and biological activity of two fragments of the very potent opioid peptide biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH<-Phe is the minimal fragment necessary to express equal affinities and the same biological activity profile as the parent biphalin. The replacement of N'-Phe with other L- or D- lipophilic amino acids showed the possibility of modification of receptor efficacy of the analogues.

Original languageEnglish (US)
Pages (from-to)2763-2766
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number18
DOIs
StatePublished - Sep 20 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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