Biological activity of some coumarins from Sri Lankan Rutaceae

Leslie Gunatilaka, David G I Kingston, E. M Kithsiri Wijeratne, B. M Ratnayake Bandara, Glenn A. Hofmann, Randall K. Johnson

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.

Original languageEnglish (US)
Pages (from-to)518-520
Number of pages3
JournalJournal of Natural Products
Volume57
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

Rutaceae
Coumarins
coumarins
Sri Lanka
DNA repair
Bioactivity
cytotoxicity
bioactive properties
Repair
bioassays
DNA Repair-Deficiency Disorders
yeasts
Bioassay
Cytotoxicity
Biological Assay
Yeast
Yeasts
DNA
seselin
xanthyletine

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Gunatilaka, L., Kingston, D. G. I., Wijeratne, E. M. K., Bandara, B. M. R., Hofmann, G. A., & Johnson, R. K. (1994). Biological activity of some coumarins from Sri Lankan Rutaceae. Journal of Natural Products, 57(4), 518-520.

Biological activity of some coumarins from Sri Lankan Rutaceae. / Gunatilaka, Leslie; Kingston, David G I; Wijeratne, E. M Kithsiri; Bandara, B. M Ratnayake; Hofmann, Glenn A.; Johnson, Randall K.

In: Journal of Natural Products, Vol. 57, No. 4, 1994, p. 518-520.

Research output: Contribution to journalArticle

Gunatilaka, L, Kingston, DGI, Wijeratne, EMK, Bandara, BMR, Hofmann, GA & Johnson, RK 1994, 'Biological activity of some coumarins from Sri Lankan Rutaceae', Journal of Natural Products, vol. 57, no. 4, pp. 518-520.
Gunatilaka L, Kingston DGI, Wijeratne EMK, Bandara BMR, Hofmann GA, Johnson RK. Biological activity of some coumarins from Sri Lankan Rutaceae. Journal of Natural Products. 1994;57(4):518-520.
Gunatilaka, Leslie ; Kingston, David G I ; Wijeratne, E. M Kithsiri ; Bandara, B. M Ratnayake ; Hofmann, Glenn A. ; Johnson, Randall K. / Biological activity of some coumarins from Sri Lankan Rutaceae. In: Journal of Natural Products. 1994 ; Vol. 57, No. 4. pp. 518-520.
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