Biological activity of some coumarins from Sri Lankan rutaceae

A. A.Leslie Gunatilaka, David G.I. Kingston, E. M.Kithsiri Wijeratne, B. M.Ratnayake Bandara, Glenn A. Hofmann, Randall K. Johnson

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.

Original languageEnglish (US)
Pages (from-to)518-520
Number of pages3
JournalJournal Of Natural Products
Volume57
Issue number4
DOIs
StatePublished - Apr 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Gunatilaka, A. A. L., Kingston, D. G. I., Wijeratne, E. M. K., Bandara, B. M. R., Hofmann, G. A., & Johnson, R. K. (1994). Biological activity of some coumarins from Sri Lankan rutaceae. Journal Of Natural Products, 57(4), 518-520. https://doi.org/10.1021/np50106a013