Biological nitric oxide signalling: Chemistry and terminology

Tassiele A. Heinrich, Roberto S. Da Silva, Katrina M Miranda, Christopher H. Switzer, David A. Wink, Jon M. Fukuto

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Biological nitrogen oxide signalling and stress is an area of extreme clinical, pharmacological, toxicological, biochemical and chemical research interest. The utility of nitric oxide and derived species as signalling agents is due to their novel and vast chemical interactions with a variety of biological targets. Herein, the chemistry associated with the interaction of the biologically relevant nitrogen oxide species with fundamental biochemical targets is discussed. Specifically, the chemical interactions of nitrogen oxides with nucleophiles (e.g. thiols), metals (e.g. hemeproteins) and paramagnetic species (e.g. dioxygen and superoxide) are addressed. Importantly, the terms associated with the mechanisms by which NO (and derived species) react with their respective biological targets have been defined by numerous past chemical studies. Thus, in order to assist researchers in referring to chemical processes associated with nitrogen oxide biology, the vernacular associated with these chemical interactions is addressed.

Original languageEnglish (US)
Pages (from-to)1417-1429
Number of pages13
JournalBritish Journal of Pharmacology
Volume169
Issue number7
DOIs
StatePublished - Aug 2013

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Terminology
Nitric Oxide
Chemical Phenomena
Nitrogen Oxides
Hemeproteins
Sulfhydryl Compounds
Superoxides
Toxicology
Metals
Research Personnel
Pharmacology
Oxygen
Research

Keywords

  • dinitrogen trioxide
  • metal nitrosyls
  • nitric oxide
  • nitrogen dioxide
  • nitrogen oxides
  • nitrosation
  • nitrosative signalling
  • nitrosative stress
  • nitrosylation
  • peroxynitrite

ASJC Scopus subject areas

  • Pharmacology

Cite this

Heinrich, T. A., Da Silva, R. S., Miranda, K. M., Switzer, C. H., Wink, D. A., & Fukuto, J. M. (2013). Biological nitric oxide signalling: Chemistry and terminology. British Journal of Pharmacology, 169(7), 1417-1429. https://doi.org/10.1111/bph.12217

Biological nitric oxide signalling : Chemistry and terminology. / Heinrich, Tassiele A.; Da Silva, Roberto S.; Miranda, Katrina M; Switzer, Christopher H.; Wink, David A.; Fukuto, Jon M.

In: British Journal of Pharmacology, Vol. 169, No. 7, 08.2013, p. 1417-1429.

Research output: Contribution to journalArticle

Heinrich, TA, Da Silva, RS, Miranda, KM, Switzer, CH, Wink, DA & Fukuto, JM 2013, 'Biological nitric oxide signalling: Chemistry and terminology', British Journal of Pharmacology, vol. 169, no. 7, pp. 1417-1429. https://doi.org/10.1111/bph.12217
Heinrich, Tassiele A. ; Da Silva, Roberto S. ; Miranda, Katrina M ; Switzer, Christopher H. ; Wink, David A. ; Fukuto, Jon M. / Biological nitric oxide signalling : Chemistry and terminology. In: British Journal of Pharmacology. 2013 ; Vol. 169, No. 7. pp. 1417-1429.
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