Abstract
Background: Critical illness and tissue injury initiate a complex series of rapid homeostatic events in an attempt to prevent ongoing tissue damage and to activate the repair process. Classically, inflammation has been recognized as the hallmark of the homeostatic response. But more recently, attention has been focused on defining the response at the cellular, metabolic, and molecular levels. Methods: Review of current literature on immunomodulating nutrition support of critically ill and injured patients. Results: There is mounting evidence regarding metabolic changes in critically ill and injured patients and their need for key nutrients and special substrates. As we refine and further define nutritional support for critically ill patients, it is imperative that we continue to pursue a deeper understanding of this field. Specifically, in order to provide timely and disease-directed nutritional support, we must elucidate the most crucial changes in acute phase proteins, cytokines, and other biochemical indices. Conclusions: It has become clear that no one formula fits all. Rather, nutritional support must be principally based on each individual patient's disease and condition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7-12 |
| Number of pages | 6 |
| Journal | European Surgery - Acta Chirurgica Austriaca |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2011 |
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Keywords
- Acute phase proteins
- Acute phase response
- Adult respiratory distress syndrome (ARDS)
- Albumin
- Amino acids
- C-reactive protein
- Catecholamine
- Cholesterol
- Cortisol
- Critical illness
- Cytokines
- Free fatty acids
- Glucagon
- Growth hormone
- Hyperglycemia
- Immune-enhancing diets
- Interleukin-6 (IL-6)
- Malnutrition
- Metabolic rate
- Negative nitrogen balance
- Nutrition monitoring
- Prealbumin
- Retinol-binding protein
- Sepsis
- Thyroid hormone
- Tumor necrosis factor
ASJC Scopus subject areas
- Surgery
Cite this
Biology-based nutritional support of critically ill and injured patients. / Dogjani, A.; Zatriqi, S.; Uranues, S.; Latifi, Rifat -.
In: European Surgery - Acta Chirurgica Austriaca, Vol. 43, No. 1, 02.2011, p. 7-12.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biology-based nutritional support of critically ill and injured patients
AU - Dogjani, A.
AU - Zatriqi, S.
AU - Uranues, S.
AU - Latifi, Rifat -
PY - 2011/2
Y1 - 2011/2
N2 - Background: Critical illness and tissue injury initiate a complex series of rapid homeostatic events in an attempt to prevent ongoing tissue damage and to activate the repair process. Classically, inflammation has been recognized as the hallmark of the homeostatic response. But more recently, attention has been focused on defining the response at the cellular, metabolic, and molecular levels. Methods: Review of current literature on immunomodulating nutrition support of critically ill and injured patients. Results: There is mounting evidence regarding metabolic changes in critically ill and injured patients and their need for key nutrients and special substrates. As we refine and further define nutritional support for critically ill patients, it is imperative that we continue to pursue a deeper understanding of this field. Specifically, in order to provide timely and disease-directed nutritional support, we must elucidate the most crucial changes in acute phase proteins, cytokines, and other biochemical indices. Conclusions: It has become clear that no one formula fits all. Rather, nutritional support must be principally based on each individual patient's disease and condition.
AB - Background: Critical illness and tissue injury initiate a complex series of rapid homeostatic events in an attempt to prevent ongoing tissue damage and to activate the repair process. Classically, inflammation has been recognized as the hallmark of the homeostatic response. But more recently, attention has been focused on defining the response at the cellular, metabolic, and molecular levels. Methods: Review of current literature on immunomodulating nutrition support of critically ill and injured patients. Results: There is mounting evidence regarding metabolic changes in critically ill and injured patients and their need for key nutrients and special substrates. As we refine and further define nutritional support for critically ill patients, it is imperative that we continue to pursue a deeper understanding of this field. Specifically, in order to provide timely and disease-directed nutritional support, we must elucidate the most crucial changes in acute phase proteins, cytokines, and other biochemical indices. Conclusions: It has become clear that no one formula fits all. Rather, nutritional support must be principally based on each individual patient's disease and condition.
KW - Acute phase proteins
KW - Acute phase response
KW - Adult respiratory distress syndrome (ARDS)
KW - Albumin
KW - Amino acids
KW - C-reactive protein
KW - Catecholamine
KW - Cholesterol
KW - Cortisol
KW - Critical illness
KW - Cytokines
KW - Free fatty acids
KW - Glucagon
KW - Growth hormone
KW - Hyperglycemia
KW - Immune-enhancing diets
KW - Interleukin-6 (IL-6)
KW - Malnutrition
KW - Metabolic rate
KW - Negative nitrogen balance
KW - Nutrition monitoring
KW - Prealbumin
KW - Retinol-binding protein
KW - Sepsis
KW - Thyroid hormone
KW - Tumor necrosis factor
UR - http://www.scopus.com/inward/record.url?scp=79958165456&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958165456&partnerID=8YFLogxK
U2 - 10.1007/s10353-011-0587-9
DO - 10.1007/s10353-011-0587-9
M3 - Article
AN - SCOPUS:79958165456
VL - 43
SP - 7
EP - 12
JO - Acta Chirurgica Austriaca
JF - Acta Chirurgica Austriaca
SN - 0001-544X
IS - 1
ER -