Biomarkers for cognitive aging part II: Oxidative stress, cognitive assessments, and medication adherence

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The purpose of this study was to further examine potential biomarkers of cognitive aging by looking at the associations among oxidative stress, cognitive abilities, and medication adherence in a community-based sample of middle-aged and older adults (n = 42; mean age = 69 years) prescribed at least one medication for hypertension. In addition to measures described in Part I, "Biomarkers for Cognitive Aging," a 12-hr urine collection for F2-isoprostanes served as an indicator of oxidative stress. Participants completed a battery of cognitive assessments and 8 weeks of electronic medication monitoring for adherence to one antihypertensive agent. Oxidative stress was significantly associated with logical memory, immediate (r = -.38, p < .01) and delayed recall (r = -.42, p < .01), and recognition memory (r = -.42, p < .01) from the Wechsler Memory Scale III, number of perseveration errors (r =.26, p < .05) and categories achieved (r = -.26, p < .01) on the Wisconsin Card Sorting Test (WSCT), and medication adherence (r = -.34, p < .05). Findings indicate that a biomarker of oxidative stress, F2-isoprostanes corrected for vitamin E, is significantly associated with cognitive measures and a functional outcome.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalBiological research for nursing
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2012

Keywords

  • adherence
  • cognition
  • hypertension
  • oxidative stress

ASJC Scopus subject areas

  • Research and Theory

Fingerprint Dive into the research topics of 'Biomarkers for cognitive aging part II: Oxidative stress, cognitive assessments, and medication adherence'. Together they form a unique fingerprint.

  • Cite this