Biometrical methods for testing dose effects of environmental stimuli in laboratory studies

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Major endpoints of ecotoxicological interest include carcinogenicity, mutagenicity, and teratogenicity. When the environmental stimulus is administered over a range of doses, it is of interest to estimate and/or test features of the dose response. In some instances, variance heterogeneity and overdispersion are present, and adjustments to the statistical methods are required. Such methods for assessing dose response for the major endpoints noted above are discussed, with emphasis directed at testing for an increasing dose response. -from Author

Original languageEnglish (US)
Pages (from-to)483-505
Number of pages23
JournalEnvironmetrics
Volume4
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Dose-response
Dose
Statistical methods
Testing
Variance Heterogeneity
Overdispersion
Statistical method
mutagenicity
Adjustment
Estimate
Range of data
laboratory
method
effect
dose

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Statistics and Probability

Cite this

Biometrical methods for testing dose effects of environmental stimuli in laboratory studies. / Piegorsch, Walter W.

In: Environmetrics, Vol. 4, No. 4, 1993, p. 483-505.

Research output: Contribution to journalArticle

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