Biometrical methods for testing dose effects of environmental stimuli in laboratory studies

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8 Scopus citations

Abstract

In the areas of toxicology and environmental biology, the damaging effects of environmental chemicals or other stimuli on biological systems are often studied in controlled laboratory experiments. These usually involve animal and microbial systems. Data from such experiments are analysed via various statistical approaches, depending on the nature of the endpoint and aspects of the particular assay under study. Major endpoints of interest include carcinogenicity, mutagenicity, and teratogenicity. When the environmental stimulus is administered over a range of doses, it is of interest to estimate and/or test features of the dose response. In some instances, variance heterogeneity and overdispersion are present, and adjustments to the statistical methods are required. Herein, such methods for assessing dose response for the major endpoints noted above are discussed, with emphasis directed at testing for an increasing dose response.

Original languageEnglish (US)
Pages (from-to)483-505
Number of pages23
JournalEnvironmetrics
Volume4
Issue number4
DOIs
StatePublished - Dec 1993
Externally publishedYes

Keywords

  • Discrete data
  • dose response
  • overdispersion
  • quantal response
  • significance test
  • trend test

ASJC Scopus subject areas

  • Statistics and Probability
  • Ecological Modeling

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