Biophysical Derangements in Genetic Cardiomyopathies

Melissa L. Lynn, Sarah J. Lehman, Jil C Tardiff

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

This article focuses on three “bins” that comprise sets of biophysical derangements elicited by cardiomyopathy-associated mutations in the myofilament. Current therapies focus on symptom palliation and do not address the disease at its core. We and others have proposed that a more nuanced classification could lead to direct interventions based on early dysregulation changing the trajectory of disease progression in the preclinical cohort. Continued research is necessary to address the complexity of cardiomyopathic progression and develop efficacious therapeutics.

Original languageEnglish (US)
Pages (from-to)147-159
Number of pages13
JournalHeart Failure Clinics
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2018

Keywords

  • Calcium signaling
  • Cardiomyopathies
  • Phosphorylation potential
  • Primary
  • Protein stability
  • Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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