Biosensor diagnosis of urinary tract infections: A path to better treatment?

Kathleen E. Mach, Pak Kin Wong, Joseph C. Liao

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Urinary tract infection (UTI) is among the most common bacterial infections and poses a significant healthcare burden. The standard culture-based diagnosis of UTI has a typical delay of two to three days. In the absence of definitive microbiological diagnosis at the point of care, physicians frequently initiate empirical broad-spectrum antibiotic treatment, and this has contributed to the emergence of resistant pathogens. Biosensors are emerging as a powerful diagnostic platform for infectious diseases. Paralleling how blood glucose sensors revolutionized the management of diabetes, and how pregnancy tests are now conducted in the home, biosensors are poised to improve UTI diagnosis significantly. Biosensors are amenable to integration with microfluidic technology for point-of-care (POC) applications. This review focuses on promising biosensor technology for UTI diagnosis, including pathogen identification and antimicrobial susceptibility testing, and hurdles to be surpassed in the translation of biosensor technology from bench to bedside.

Original languageEnglish (US)
Pages (from-to)330-336
Number of pages7
JournalTrends in Pharmacological Sciences
Volume32
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Biosensing Techniques
Biosensors
Urinary Tract Infections
Point-of-Care Systems
Pathogens
Glucose sensors
Technology
Pregnancy Tests
Therapeutics
Microfluidics
Medical problems
Bacterial Infections
Communicable Diseases
Blood Glucose
Anti-Bacterial Agents
Delivery of Health Care
Physicians
Testing

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Biosensor diagnosis of urinary tract infections : A path to better treatment? / Mach, Kathleen E.; Wong, Pak Kin; Liao, Joseph C.

In: Trends in Pharmacological Sciences, Vol. 32, No. 6, 06.2011, p. 330-336.

Research output: Contribution to journalArticle

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