Biosensors for Monitoring Airborne Pathogens

Xianting Ding, Christopher F. Fronczek, Jeong-Yeol Yoon

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Airborne pathogens affect both humans and animals and are often highly and rapidly transmittable. Many problematic airborne pathogens, both viral (influenza A/H1N1, Rubella, and avian influenza/H5N1) and bacterial (Mycobacterium tuberculosis, Streptococcus pneumoniae, and Bacillus anthracis), have huge impacts on health care and agricultural applications, and can potentially be used as bioterrorism agents. Many different laboratory-based methods have been introduced and are currently being used. However, such detection is generally limited by sample collection, including nasal swabs and blood analysis. Direct identification from air (specifically, aerosol samples) would be ideal, but such detection has not been very successful due to the difficulty in sample collection and the extremely low pathogen concentration found in aerosol samples. In this review, we will discuss the portable biosensors and/or micro total analysis systems (µTAS) that can be used for monitoring such airborne pathogens, similar to smoke detectors. Current laboratory-based methods will be reviewed, and possible solutions to convert these lab-based methods into µTAS biosensors will be discussed.

Original languageEnglish (US)
Pages (from-to)390-410
Number of pages21
JournalJournal of laboratory automation
Volume20
Issue number4
DOIs
StatePublished - Aug 25 2015

Keywords

  • aerosol
  • anthrax
  • influenza
  • micro total analysis system
  • pneumonia
  • Rubella
  • tuberculosis

ASJC Scopus subject areas

  • Computer Science Applications
  • Medical Laboratory Technology

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