Biosynthesis of pyrrolopyrimidines

Reid M. McCarty, Vahe Bandarian

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of purine-based metabolites that have been isolated from a variety of biological sources and have diverse functions which range from secondary metabolism to RNA modification. To date, nearly 35 compounds with the common 7-deazapurine core structure have been described. This article will illustrate the structural diversity of these compounds and review the current state of knowledge on the biosynthetic pathways that give rise to them.

Original languageEnglish (US)
Pages (from-to)15-25
Number of pages11
JournalBioorganic Chemistry
Volume43
DOIs
StatePublished - Aug 1 2012

Keywords

  • 7-Deazapurine in secondary metabolism
  • 7-Deazapurines in tRNA
  • Biosynthesis of 7-deazapurines

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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