Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of purine-based metabolites that have been isolated from a variety of biological sources and have diverse functions which range from secondary metabolism to RNA modification. To date, nearly 35 compounds with the common 7-deazapurine core structure have been described. This article will illustrate the structural diversity of these compounds and review the current state of knowledge on the biosynthetic pathways that give rise to them.
- 7-Deazapurine in secondary metabolism
- 7-Deazapurines in tRNA
- Biosynthesis of 7-deazapurines
ASJC Scopus subject areas
- Molecular Biology
- Drug Discovery
- Organic Chemistry