Biosynthesis of the antitumor antibiotic CC-1065 by Streptomyces zelensis

Laurence Hurley, J. S. Rokem

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The biosynthesis is the antitumor antibiotic, CC-1065, has been investigated by radioactive isotope techniques, in combination with chemical degradation of CC-1065. Tyrosine, dopa, serine and methionine (S-CH3 group) have been shown to be precursors of CC-1065. Tyrosine is proposed to be a precursor of all three benzodipyrrole subunits, while dopa is only apparently incorporated into subunits B and C. Serine is postulated to contribute three 2C units, with loss of C-1, to all three subunits of CC-1065. The S-CH3 group of methionine probably contributes four C-1 units to CC-1065 of which one is incorporated with considerable loss of tritium, most probably into the cyclopropane ring of subunit A.

Original languageEnglish (US)
Pages (from-to)383-390
Number of pages8
JournalJournal of Antibiotics
Volume36
Issue number4
StatePublished - 1983
Externally publishedYes

Fingerprint

CC 1065
Streptomyces
Anti-Bacterial Agents
Dihydroxyphenylalanine
Methionine
Serine
Tyrosine
Tritium
Radioisotopes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Biosynthesis of the antitumor antibiotic CC-1065 by Streptomyces zelensis. / Hurley, Laurence; Rokem, J. S.

In: Journal of Antibiotics, Vol. 36, No. 4, 1983, p. 383-390.

Research output: Contribution to journalArticle

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