Bleomycin, vincristine, mitomycin C and cis-platinum in gynecologic squamous cell carcinomas: A high incidence of pulmonary toxicity

Setsuko K Chambers, Stuart D Flynn, Salvatore A. Del Prete, Joseph T. Chambers, Peter E. Schwartz

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Twenty-three patients with gynecologic squamous cell carcinomas (20 cervical, 2 vulvar, 1 ovarian) were treated with bleomycin, vincristine, mitomycin-C, and cis-platinum. Twenty-one patients had prior radiation therapy. Of the 21 evaluable patients, the response rate was 48% with a median duration of 4 months. Toxicity in the 23 patients was high, with the most significant being that of pulmonary toxicity. Eight patients had pulmonary toxicity with 5 of 8 dying a respiratory death while free of disease. Bleomycin is excreted primarily by the kidneys, and its half-life is known to increase in patients with renal insufficiency. Patients with advanced, recurrent cervical cancer who have failed radiation therapy often have underlying renal compromise. Extreme caution should be exercised when administering bleomycin with nephrotoxic chemotherapeutic agents in this setting.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalGynecologic Oncology
Volume32
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

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Bleomycin
Mitomycin
Vincristine
Cisplatin
Squamous Cell Carcinoma
Lung
Incidence
Radiotherapy
Kidney
Uterine Cervical Neoplasms
Renal Insufficiency
Half-Life

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Bleomycin, vincristine, mitomycin C and cis-platinum in gynecologic squamous cell carcinomas : A high incidence of pulmonary toxicity. / Chambers, Setsuko K; Flynn, Stuart D; Del Prete, Salvatore A.; Chambers, Joseph T.; Schwartz, Peter E.

In: Gynecologic Oncology, Vol. 32, No. 3, 1989, p. 303-309.

Research output: Contribution to journalArticle

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