Blockade of opioid-induced changes in auditory function at the level of the cochlea

Tony L. Sahley, Richard H. Nodar, Frank E. Musiek

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: We have previously investigated the auditory neural effects of the κ-opioid receptor agonist, (-)pentazocine. When administered intravenously (iv), this drug temporarily alters auditory nerve compound action potential (CAP) amplitudes. To test the hypothesis that the observed neural effects of iv (-)pentazocine occur via κ-receptor interactions within the cochlea, we attempted to block these effects by employing a specific κ- opioid receptor antagonist applied directly to the cochlear round window (RW) membrane. Design: In 31 normal-hearing, male pigmented chinchillas, amplitude changes in the click-evoked auditory CAP (N1) were tracked at six stimulus intensities during a baseline and a postbaseline period in which iv (- )pentazocine (8 mg/kg) was administered. (-)Pentazocine administration was preceded by the delivery to the cochlear RW membrane of an artificial perilymph solution given alone or containing the κ-opioid receptor selective antagonist, norbinaltorphimine (Nor-BNI), which was administered at two concentrations in separate groups of animals. Results: The amplitude increase in the CAP after (-)pentazocine was significantly reduced when iv (- )pentazocine was preceded by RW-administered Nor-BNI (4 mM). Conclusions: The reversibility of agonist effects by Nor-BNI indicates direct or indirect opioid K-receptor-mediated auditory neural effects at the level of the cochlea and suggests a connection between κ-receptors and auditory neural function.

Original languageEnglish (US)
Pages (from-to)552-558
Number of pages7
JournalEar and hearing
Volume17
Issue number6
DOIs
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing

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