Blocking candida adherence to contact lenses

Salim I. Butrus, Stephen A Klotz

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The adherence of microorganisms to contact lenses may be an important initial step in the pathogenesis of contact lens-associated infectious keratitis. Using a strain of Candida albicans whose interaction with various polymers has been well characterized we systematically investigated the adherence of this pathogen to hard hydrophobic and soft hydrophilic extended-wear contact lenses. Yeasts adhere to the hydrophobic lenses in direct proportion to the wetting angle of the lens whereas yeasts adhere to the hydrophilic lenses in direct proportion to the water content of the lens. Tear proteins such as albumin, lactoferrin, and lysozyme in addition to fibronectin enhance yeast adherence to both types of lenses (P<0.01). Concanavalin A reduces adherence of yeasts to both lens types (P<0.01). Among tear components however, only mucin (0.5% consistently reduced yeast adherence to both lens types. Hydrophilic extended wear lenses worn for at least 28 days by normal patients consistently had greater adherence of yeasts than unworn lenses of the same type, often as much as ten-fold or greater yeasts/mm2 of lens surface area (P < 0.05). These investigations indicate that tear components both in solution and adsorbed to the lens surface enhance microorganism adherence to contact lenses.

Original languageEnglish (US)
Pages (from-to)745-750
Number of pages6
JournalCurrent Eye Research
Volume5
Issue number10
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Contact Lenses
Candida
Lenses
Yeasts
Tears
Extended-Wear Contact Lenses
Hydrophilic Contact Lens
Lactoferrin
Keratitis
Mucins
Muramidase
Concanavalin A
Candida albicans
Fibronectins
Albumins
Polymers

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Blocking candida adherence to contact lenses. / Butrus, Salim I.; Klotz, Stephen A.

In: Current Eye Research, Vol. 5, No. 10, 1986, p. 745-750.

Research output: Contribution to journalArticle

Butrus, Salim I. ; Klotz, Stephen A. / Blocking candida adherence to contact lenses. In: Current Eye Research. 1986 ; Vol. 5, No. 10. pp. 745-750.
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