Body shape, adiposity index, and mortality in postmenopausal women

Findings from the Women's Health Initiative

Cynthia Thomson, David O. Garcia, Betsy C. Wertheim, Melanie D Hingle, Jennifer W Bea, Oleg Zaslavsky, Graciela Caire-Juvera, Thomas Rohan, Mara Z. Vitolins, Patricia A. Thompson, Cora E. Lewis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Studies evaluating the relationship between body mass index (BMI) and mortality demonstrate a U-shaped association. To expand, this study evaluated the relationship between adiposity indices, a body shape index (ABSI) and body adiposity index (BAI), and mortality in 77,505 postmenopausal women. Methods: A prospective cohort analysis was conducted in the Women's Health Initiative to ascertain the independent relationships between adiposity indices and mortality in order to inform on the clinical usefulness of alternate measures of mortality risk. ABSI (waist circumference (cm)/[BMI2/3 × height (cm)1/2]), BAI (hip circumference (cm)/[height (m)1.5] - 18), weight, BMI, and waist circumference (WC) were evaluated in relation to mortality risk using adjusted Cox proportional hazards regression models. Results: ABSI showed a linear association with mortality (HR, 1.37; 95% CI, 1.28-1.47 for quintile 5 vs. 1) while BMI and BAI had U-shaped relationships with HR of 1.30; 95% CI, 1.20-1.40 for obesity II/III BMI and 1.06, 95% CI, 0.99-1.13 for BAI. Higher WC (HR, 1.21; 95% CI, 1.13-1.29 for quintile 5 vs. 1) showed relationships similar to BMI. Conclusions: ABSI appears to be a clinically useful measure for estimating mortality risk, perhaps more so than BAI and BMI in postmenopausal women.

Original languageEnglish (US)
JournalObesity
DOIs
StateAccepted/In press - 2016

Fingerprint

Adiposity
Women's Health
Body Mass Index
Mortality
Waist Circumference
Proportional Hazards Models
Hip
Cohort Studies
Obesity
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Body shape, adiposity index, and mortality in postmenopausal women : Findings from the Women's Health Initiative. / Thomson, Cynthia; Garcia, David O.; Wertheim, Betsy C.; Hingle, Melanie D; Bea, Jennifer W; Zaslavsky, Oleg; Caire-Juvera, Graciela; Rohan, Thomas; Vitolins, Mara Z.; Thompson, Patricia A.; Lewis, Cora E.

In: Obesity, 2016.

Research output: Contribution to journalArticle

Thomson, Cynthia ; Garcia, David O. ; Wertheim, Betsy C. ; Hingle, Melanie D ; Bea, Jennifer W ; Zaslavsky, Oleg ; Caire-Juvera, Graciela ; Rohan, Thomas ; Vitolins, Mara Z. ; Thompson, Patricia A. ; Lewis, Cora E. / Body shape, adiposity index, and mortality in postmenopausal women : Findings from the Women's Health Initiative. In: Obesity. 2016.
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abstract = "Objective: Studies evaluating the relationship between body mass index (BMI) and mortality demonstrate a U-shaped association. To expand, this study evaluated the relationship between adiposity indices, a body shape index (ABSI) and body adiposity index (BAI), and mortality in 77,505 postmenopausal women. Methods: A prospective cohort analysis was conducted in the Women's Health Initiative to ascertain the independent relationships between adiposity indices and mortality in order to inform on the clinical usefulness of alternate measures of mortality risk. ABSI (waist circumference (cm)/[BMI2/3 × height (cm)1/2]), BAI (hip circumference (cm)/[height (m)1.5] - 18), weight, BMI, and waist circumference (WC) were evaluated in relation to mortality risk using adjusted Cox proportional hazards regression models. Results: ABSI showed a linear association with mortality (HR, 1.37; 95{\%} CI, 1.28-1.47 for quintile 5 vs. 1) while BMI and BAI had U-shaped relationships with HR of 1.30; 95{\%} CI, 1.20-1.40 for obesity II/III BMI and 1.06, 95{\%} CI, 0.99-1.13 for BAI. Higher WC (HR, 1.21; 95{\%} CI, 1.13-1.29 for quintile 5 vs. 1) showed relationships similar to BMI. Conclusions: ABSI appears to be a clinically useful measure for estimating mortality risk, perhaps more so than BAI and BMI in postmenopausal women.",
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