Bone cancer pain.

Denis R. Clohisy, Patrick W Mantyh

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

BACKGROUND: Bone cancer pain is very common, and patients with this type of pain may be difficult to treat. Development of an experimental model for studying this condition is critical to advancing an understanding of the mechanisms that cause pain in patients with malignant disease. METHODS: A murine model of bone cancer was studied. Combined analysis of the extent of tumor-induced bone destruction, pain, and neurochemical characterization of the peripheral and central nervous systems was performed to investigate bone cancer pain. Disease-induced bone destruction was assessed by radiographs and histomorphometry. Pain was assessed by spontaneous and elicited behaviors, and neurochemical analysis involved immunohistochemical detection of hyperalgesic peptides and neurochemical markers. RESULTS: Mice with distal femoral sarcomas exhibited behavioral and neurochemical measures of pain. The pain condition created by malignant bone disease was distinct neurochemically from inflammatory and neuropathic pain states. Experimental evidence indicated that both disease-induced osteolysis and tumors themselves contributed to the generation of pain and that peripheral and central sensitization of the nervous system was present. CONCLUSIONS: Malignant bone disease creates a unique pain state that involves sensitization of the nervous system. Major contributors to the pain state within the bone tissue are osteoclastic bone resorption and the malignant disease itself.

Original languageEnglish (US)
JournalClinical Orthopaedics and Related Research
Issue number415 Suppl
StatePublished - Oct 2003
Externally publishedYes

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Bone Neoplasms
Pain
Bone Diseases
Central Nervous System Sensitization
Cancer Pain
Bone and Bones
Osteolysis
Peripheral Nervous System
Neuralgia
Bone Resorption
Thigh
Sarcoma
Nervous System
Neoplasms
Theoretical Models
Central Nervous System
Peptides

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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Bone cancer pain. / Clohisy, Denis R.; Mantyh, Patrick W.

In: Clinical Orthopaedics and Related Research, No. 415 Suppl, 10.2003.

Research output: Contribution to journalArticle

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