Bone marrow origin of Ia molecules purified from epidermal cells

J. A. Frelinger, J. G. Frelinger

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Using radiation bone marrow chimeras, we have shown that Ia molecules purified from epidermal cell preparations of the mouse reflect the Ia phenotype of the bone marrow donor. This result strongly suggests that Ia molecules are synthesized by a bone-marrow-derived cell in the epidermis. Furthermore, results of peptide map analysis of immunoprecipitated biosynthetically labeled Ia suggest that the Ia molecules found in skin are identical to those found on B lymphocytes. These results support biochemical as well as serological identity.

Original languageEnglish (US)
Pages (from-to)68-70
Number of pages3
JournalJournal of Investigative Dermatology
Volume75
Issue number1
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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