Bone marrow origin of Ia molecules purified from epidermal cells

Jeffrey A Frelinger, J. G. Frelinger

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Using radiation bone marrow chimeras, we have shown that Ia molecules purified from epidermal cell preparations of the mouse reflect the Ia phenotype of the bone marrow donor. This result strongly suggests that Ia molecules are synthesized by a bone-marrow-derived cell in the epidermis. Furthermore, results of peptide map analysis of immunoprecipitated biosynthetically labeled Ia suggest that the Ia molecules found in skin are identical to those found on B lymphocytes. These results support biochemical as well as serological identity.

Original languageEnglish (US)
Pages (from-to)68-70
Number of pages3
JournalJournal of Investigative Dermatology
Volume75
Issue number1
StatePublished - 1980
Externally publishedYes

Fingerprint

Bone
Bone Marrow
Molecules
Epidermis
Bone Marrow Cells
B-Lymphocytes
Lymphocytes
Radiation
Phenotype
Skin
Peptides

ASJC Scopus subject areas

  • Dermatology

Cite this

Bone marrow origin of Ia molecules purified from epidermal cells. / Frelinger, Jeffrey A; Frelinger, J. G.

In: Journal of Investigative Dermatology, Vol. 75, No. 1, 1980, p. 68-70.

Research output: Contribution to journalArticle

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