Bone remodeling in CAII deficient and calbindin-D28k KO mice

D. S. Margolis, John Szivek, Y. H. Lien, Li-Wen Lai, G. A. Kastis, Harrison H Barrett

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Two genetically altered mice were studied to determine the effects of inhibited osteoclast and osteoblast function on bone phenotype. Carbonic anhydrase II (CAII) deficient mice were used as a model of inhibited osteoclast function as CAII is a key enzyme used to acidify resorption lacunae and activate the lysosomal enzymes that resorb bone. Calbindin-D28k knockout mice were also studied. Calbindin-D28k is a protein that is expressed in osteoblasts and has been shown to mitigate osteoblast apoptosis.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages797
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

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Carbonic anhydrase
Osteoblasts
Bone
Enzymes
Cell death
Proteins
Osteoclasts

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Margolis, D. S., Szivek, J., Lien, Y. H., Lai, L-W., Kastis, G. A., & Barrett, H. H. (2004). Bone remodeling in CAII deficient and calbindin-D28k KO mice. In Transactions - 7th World Biomaterials Congress (pp. 797)

Bone remodeling in CAII deficient and calbindin-D28k KO mice. / Margolis, D. S.; Szivek, John; Lien, Y. H.; Lai, Li-Wen; Kastis, G. A.; Barrett, Harrison H.

Transactions - 7th World Biomaterials Congress. 2004. p. 797.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Margolis, DS, Szivek, J, Lien, YH, Lai, L-W, Kastis, GA & Barrett, HH 2004, Bone remodeling in CAII deficient and calbindin-D28k KO mice. in Transactions - 7th World Biomaterials Congress. pp. 797, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Margolis DS, Szivek J, Lien YH, Lai L-W, Kastis GA, Barrett HH. Bone remodeling in CAII deficient and calbindin-D28k KO mice. In Transactions - 7th World Biomaterials Congress. 2004. p. 797
Margolis, D. S. ; Szivek, John ; Lien, Y. H. ; Lai, Li-Wen ; Kastis, G. A. ; Barrett, Harrison H. / Bone remodeling in CAII deficient and calbindin-D28k KO mice. Transactions - 7th World Biomaterials Congress. 2004. pp. 797
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