Bootstrap methods for simultaneous benchmark analysis with quantal response data

R. Webster West, Daniela K. Nitcheva, Walter W Piegorsch

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A primary objective in quantitative risk assessment is the characterization of risk which is defined to be the likelihood of an adverse effect caused by an environmental toxin or chemcial agent. In modern risk-benchmark analysis, attention centers on the "benchmark dose" at which a fixed benchmark level of risk is achieved, with a lower confidence limits on this dose being of primary interest. In practice, a range of benchmark risks may be under study, so that the individual lower confidence limits on benchmark dose must be corrected for simultaneity in order to maintain a specified overall level of confidence. For the case of quantal data, simultaneous methods have been constructed that appeal to the large sample normality of parameter estimates. The suitability of these methods for use with small sample sizes will be considered. A new bootstrap technique is proposed as an alternative to the large sample methodology. This technique is evaluated via a simulation study and examples from environmental toxicology.

Original languageEnglish (US)
Pages (from-to)63-73
Number of pages11
JournalEnvironmental and Ecological Statistics
Volume16
Issue number1
DOIs
Publication statusPublished - 2009

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Keywords

  • Benchmark dose
  • Bootstrap
  • Multistage model
  • Quantal data
  • Quantitative risk assessment
  • Simultaneous inferences

ASJC Scopus subject areas

  • Environmental Science(all)
  • Statistics, Probability and Uncertainty
  • Statistics and Probability

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