Brain cognition and metabolism in Down syndrome adults in association with development of dementia

A. Dani, P. Pietrini, M. L. Furey, A. R. McIntosh, C. L. Grady, B. Horwitz, U. Freo, Gene E Alexander, M. B. Schapiro

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To identify changes in brain functions associated with the development of dementia, brain metabolism and cognition were assessed repeatedly in 12 adults with Down syndrome (DS) using positron emission tomography and neuropsychological tests. Ten subjects remained non-demented (ND) and showed no significant changes over time in cognitive measures or in cerebral metabolism. Two subjects developed dementia after 7 years. Brain functions were relatively stable prior to the onset of dementia; after the onset of dementia, both cognitive function and glucose metabolism in parietal and temporal brain regions known to be vulnerable to Alzheimer disease (AD) showed a rapid linear decline. These findings support the concept that brain functions are stable over time in ND individuals with DS and that decline of brain functions in DS subjects with dementia follows two distinct phases that correspond to the clinical progression of AD. This may have implications for timing of new therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)2933-2936
Number of pages4
JournalNeuroReport
Volume7
Issue number18
StatePublished - 1996
Externally publishedYes

Fingerprint

Down Syndrome
Cognition
Dementia
Brain
Alzheimer Disease
Neuropsychological Tests
Temporal Lobe
Positron-Emission Tomography
Glucose

Keywords

  • FDG
  • Brain
  • Chromosome 21
  • Dementia
  • Down syndrome
  • PET

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dani, A., Pietrini, P., Furey, M. L., McIntosh, A. R., Grady, C. L., Horwitz, B., ... Schapiro, M. B. (1996). Brain cognition and metabolism in Down syndrome adults in association with development of dementia. NeuroReport, 7(18), 2933-2936.

Brain cognition and metabolism in Down syndrome adults in association with development of dementia. / Dani, A.; Pietrini, P.; Furey, M. L.; McIntosh, A. R.; Grady, C. L.; Horwitz, B.; Freo, U.; Alexander, Gene E; Schapiro, M. B.

In: NeuroReport, Vol. 7, No. 18, 1996, p. 2933-2936.

Research output: Contribution to journalArticle

Dani, A, Pietrini, P, Furey, ML, McIntosh, AR, Grady, CL, Horwitz, B, Freo, U, Alexander, GE & Schapiro, MB 1996, 'Brain cognition and metabolism in Down syndrome adults in association with development of dementia', NeuroReport, vol. 7, no. 18, pp. 2933-2936.
Dani A, Pietrini P, Furey ML, McIntosh AR, Grady CL, Horwitz B et al. Brain cognition and metabolism in Down syndrome adults in association with development of dementia. NeuroReport. 1996;7(18):2933-2936.
Dani, A. ; Pietrini, P. ; Furey, M. L. ; McIntosh, A. R. ; Grady, C. L. ; Horwitz, B. ; Freo, U. ; Alexander, Gene E ; Schapiro, M. B. / Brain cognition and metabolism in Down syndrome adults in association with development of dementia. In: NeuroReport. 1996 ; Vol. 7, No. 18. pp. 2933-2936.
@article{463414ea20e448ab9d1cafbc5596b76e,
title = "Brain cognition and metabolism in Down syndrome adults in association with development of dementia",
abstract = "To identify changes in brain functions associated with the development of dementia, brain metabolism and cognition were assessed repeatedly in 12 adults with Down syndrome (DS) using positron emission tomography and neuropsychological tests. Ten subjects remained non-demented (ND) and showed no significant changes over time in cognitive measures or in cerebral metabolism. Two subjects developed dementia after 7 years. Brain functions were relatively stable prior to the onset of dementia; after the onset of dementia, both cognitive function and glucose metabolism in parietal and temporal brain regions known to be vulnerable to Alzheimer disease (AD) showed a rapid linear decline. These findings support the concept that brain functions are stable over time in ND individuals with DS and that decline of brain functions in DS subjects with dementia follows two distinct phases that correspond to the clinical progression of AD. This may have implications for timing of new therapeutic strategies.",
keywords = "FDG, Brain, Chromosome 21, Dementia, Down syndrome, PET",
author = "A. Dani and P. Pietrini and Furey, {M. L.} and McIntosh, {A. R.} and Grady, {C. L.} and B. Horwitz and U. Freo and Alexander, {Gene E} and Schapiro, {M. B.}",
year = "1996",
language = "English (US)",
volume = "7",
pages = "2933--2936",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "18",

}

TY - JOUR

T1 - Brain cognition and metabolism in Down syndrome adults in association with development of dementia

AU - Dani, A.

AU - Pietrini, P.

AU - Furey, M. L.

AU - McIntosh, A. R.

AU - Grady, C. L.

AU - Horwitz, B.

AU - Freo, U.

AU - Alexander, Gene E

AU - Schapiro, M. B.

PY - 1996

Y1 - 1996

N2 - To identify changes in brain functions associated with the development of dementia, brain metabolism and cognition were assessed repeatedly in 12 adults with Down syndrome (DS) using positron emission tomography and neuropsychological tests. Ten subjects remained non-demented (ND) and showed no significant changes over time in cognitive measures or in cerebral metabolism. Two subjects developed dementia after 7 years. Brain functions were relatively stable prior to the onset of dementia; after the onset of dementia, both cognitive function and glucose metabolism in parietal and temporal brain regions known to be vulnerable to Alzheimer disease (AD) showed a rapid linear decline. These findings support the concept that brain functions are stable over time in ND individuals with DS and that decline of brain functions in DS subjects with dementia follows two distinct phases that correspond to the clinical progression of AD. This may have implications for timing of new therapeutic strategies.

AB - To identify changes in brain functions associated with the development of dementia, brain metabolism and cognition were assessed repeatedly in 12 adults with Down syndrome (DS) using positron emission tomography and neuropsychological tests. Ten subjects remained non-demented (ND) and showed no significant changes over time in cognitive measures or in cerebral metabolism. Two subjects developed dementia after 7 years. Brain functions were relatively stable prior to the onset of dementia; after the onset of dementia, both cognitive function and glucose metabolism in parietal and temporal brain regions known to be vulnerable to Alzheimer disease (AD) showed a rapid linear decline. These findings support the concept that brain functions are stable over time in ND individuals with DS and that decline of brain functions in DS subjects with dementia follows two distinct phases that correspond to the clinical progression of AD. This may have implications for timing of new therapeutic strategies.

KW - FDG

KW - Brain

KW - Chromosome 21

KW - Dementia

KW - Down syndrome

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=0030454473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030454473&partnerID=8YFLogxK

M3 - Article

C2 - 9116213

AN - SCOPUS:0030454473

VL - 7

SP - 2933

EP - 2936

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 18

ER -