Brain Ia antigens have a bone marrow origin

Jenny P Y Ting, Douglas F. Nixon, Leslie P. Weiner, Jeffrey A Frelinger

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Our results, using radiation-induced bone marrow chimeras, demonstrate that the la antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of la in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalImmunogenetics
Volume17
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

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Histocompatibility Antigens Class II
Bone Marrow
Brain
Bone Marrow Cells
Immunoglobulin M
B-Lymphocytes
Central Nervous System
Radiation
Antigens

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

Brain Ia antigens have a bone marrow origin. / Ting, Jenny P Y; Nixon, Douglas F.; Weiner, Leslie P.; Frelinger, Jeffrey A.

In: Immunogenetics, Vol. 17, No. 3, 1983, p. 295-301.

Research output: Contribution to journalArticle

Ting, JPY, Nixon, DF, Weiner, LP & Frelinger, JA 1983, 'Brain Ia antigens have a bone marrow origin', Immunogenetics, vol. 17, no. 3, pp. 295-301. https://doi.org/10.1007/BF00364413
Ting, Jenny P Y ; Nixon, Douglas F. ; Weiner, Leslie P. ; Frelinger, Jeffrey A. / Brain Ia antigens have a bone marrow origin. In: Immunogenetics. 1983 ; Vol. 17, No. 3. pp. 295-301.
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