Brain lymphatic drainage system in fetus and newborn: Birth of a new era of exploration

L. C. De Angelis, Marlys H Witte, T. Bellini, Michael J Bernas, F. Boccardo, L. A. Ramenghi, C. Bellini

Research output: Contribution to journalArticle

Abstract

A peculiar brain lymphatic drainage system has been recently fully recognized in animals and humans. It comprises different draining pathways, including the lymphatic system, the perivascular drainage pathway, and the cerebrospinal fluid (CSF) drainage routes. Although scant data are available about its function during the neonatal period, it may play a role in neonatal brain diseases. In this review, we focus on the actual knowledge of brain lymphatic drainage system, and we hypothesize potential implications of its impairment and dysfunction in major neonatal neurological diseases.

Original languageEnglish (US)
Pages (from-to)140-147
Number of pages8
JournalLymphology
Volume51
Issue number4
StatePublished - Jan 1 2018

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Keywords

  • brain injury
  • brain lymphatic drainage system
  • cerebrospinal fluid drainage
  • fetal development
  • glymphatic system
  • neonates
  • schematic

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

Cite this

De Angelis, L. C., Witte, M. H., Bellini, T., Bernas, M. J., Boccardo, F., Ramenghi, L. A., & Bellini, C. (2018). Brain lymphatic drainage system in fetus and newborn: Birth of a new era of exploration. Lymphology, 51(4), 140-147.