Brain Natriuretic Peptide and Cyclic Guanosine-3′,5′ Monophosphate in Preeclampsia

Michele R. Lauria, Cynthia A. Standley, Yoram Sorokin, Jill C. Todt, Sidney F. Bottoms, Frank D. Yelian, David B. Cotton

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The objective of this study is to determine the possibility that pre-eclampsia, a disease characterized by altered vascular tone, may result in altered levels of fetal BNP and cGMP, and to determine whether pre-eclampsia alters the maternal-fetal relationship of BNP and cGMP. Paired maternal and umbilical venous plasma levels of BNP and cGMP were determined in 13 preeclamptic and 9 normotensive primigravidas in the third trimester. Statistical analysis was performed using multivariate analysis of variance, linear regression, and canonical correlation. Overall, levels of cGMP were lower in pre-eclampsia (P < 0.03). Pre-eclampsia was also associated with an altered maternal-fetal relationship for BNP and cGMP (P < 0.008, P < 0.02, respectively). With preeclampsia, the maternahfetal ratio was reduced for BNP and was increased for cGMP. Because of its role as a second messenger for many vasoactive hormones, we hypothesize that fetal cGMP levels may better reflect overall vascular tone than do individual hormones. Altered BNP and cGMP maternal-fetal homeostasis raises the possibility of maternal-fetal coordination of vascular control.

Original languageEnglish (US)
Pages (from-to)128-131
Number of pages4
JournalJournal of Maternal-Fetal Medicine
Issue number3
StatePublished - Jan 1 1996


  • Atrial natriuretic peptide
  • Brain natriuretic peptide
  • Cyclic guanosine-3′,5′ monophosphate
  • Pre-eclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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