Brain natriuretic peptide and cyclic guanosine-3′,5′ monophosphate in pre-eclampsia

Michele R. Lauria, Cynthia A Standley, Yoram Sorokin, Jill C. Todt, Sidney F. Bottoms, Frank D. Yelian, David B. Cotton

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The objective of this study is to determine the possibility that pre-eclampsia, a disease characterized by altered vascular tone, may result in altered levels of fetal BNP and cGMP, and to determine whether pre-eclampsia alters the maternal-fetal relationship of BNP and cGMP. Paired maternal and umbilical venous plasma levels of BNP and cGMP were determined in 13 pre-eclamptic and 9 normotensive primigravidas in the third trimester. Statistical analysis was performed using multivariate analysis of variance, linear regression, and canonical correlation. Overall, levels of cGMP were lower in pre-eclampsia (P < 0.03). Pre-eclampsia was also associated with an altered maternal-fetal relationship for BNP and cGMP (P < 0.008, P < 0.02, respectively). With pre-eclampsia, the maternal:fetal ratio was reduced for BNP and was increased for cGMP. Because of its role as a second messenger for many vasoactive hormones, we hypothesize that fetal cGMP levels may better reflect overall vascular tone than do individual hormones. Altered BNP and cGMP maternal-fetal homeostasis raises the possibility of maternal-fetal coordination of vascular control.

Original languageEnglish (US)
Pages (from-to)128-131
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume5
Issue number3
StatePublished - May 1996
Externally publishedYes

Fingerprint

Guanosine Monophosphate
Brain Natriuretic Peptide
Pre-Eclampsia
Mothers
Blood Vessels
Hormones
Umbilicus
Third Pregnancy Trimester
Second Messenger Systems
Linear Models
Analysis of Variance
Homeostasis
Multivariate Analysis

Keywords

  • Atrial natriuretic peptide
  • Brain natriuretic peptide
  • Cyclic guanosine-3′,5′ monophosphate
  • Pre-eclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Lauria, M. R., Standley, C. A., Sorokin, Y., Todt, J. C., Bottoms, S. F., Yelian, F. D., & Cotton, D. B. (1996). Brain natriuretic peptide and cyclic guanosine-3′,5′ monophosphate in pre-eclampsia. Journal of Maternal-Fetal and Neonatal Medicine, 5(3), 128-131.

Brain natriuretic peptide and cyclic guanosine-3′,5′ monophosphate in pre-eclampsia. / Lauria, Michele R.; Standley, Cynthia A; Sorokin, Yoram; Todt, Jill C.; Bottoms, Sidney F.; Yelian, Frank D.; Cotton, David B.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 5, No. 3, 05.1996, p. 128-131.

Research output: Contribution to journalArticle

Lauria, MR, Standley, CA, Sorokin, Y, Todt, JC, Bottoms, SF, Yelian, FD & Cotton, DB 1996, 'Brain natriuretic peptide and cyclic guanosine-3′,5′ monophosphate in pre-eclampsia', Journal of Maternal-Fetal and Neonatal Medicine, vol. 5, no. 3, pp. 128-131.
Lauria, Michele R. ; Standley, Cynthia A ; Sorokin, Yoram ; Todt, Jill C. ; Bottoms, Sidney F. ; Yelian, Frank D. ; Cotton, David B. / Brain natriuretic peptide and cyclic guanosine-3′,5′ monophosphate in pre-eclampsia. In: Journal of Maternal-Fetal and Neonatal Medicine. 1996 ; Vol. 5, No. 3. pp. 128-131.
@article{f739ef22617f4a8b9a2ac16e7334f2c2,
title = "Brain natriuretic peptide and cyclic guanosine-3′,5′ monophosphate in pre-eclampsia",
abstract = "The objective of this study is to determine the possibility that pre-eclampsia, a disease characterized by altered vascular tone, may result in altered levels of fetal BNP and cGMP, and to determine whether pre-eclampsia alters the maternal-fetal relationship of BNP and cGMP. Paired maternal and umbilical venous plasma levels of BNP and cGMP were determined in 13 pre-eclamptic and 9 normotensive primigravidas in the third trimester. Statistical analysis was performed using multivariate analysis of variance, linear regression, and canonical correlation. Overall, levels of cGMP were lower in pre-eclampsia (P < 0.03). Pre-eclampsia was also associated with an altered maternal-fetal relationship for BNP and cGMP (P < 0.008, P < 0.02, respectively). With pre-eclampsia, the maternal:fetal ratio was reduced for BNP and was increased for cGMP. Because of its role as a second messenger for many vasoactive hormones, we hypothesize that fetal cGMP levels may better reflect overall vascular tone than do individual hormones. Altered BNP and cGMP maternal-fetal homeostasis raises the possibility of maternal-fetal coordination of vascular control.",
keywords = "Atrial natriuretic peptide, Brain natriuretic peptide, Cyclic guanosine-3′,5′ monophosphate, Pre-eclampsia",
author = "Lauria, {Michele R.} and Standley, {Cynthia A} and Yoram Sorokin and Todt, {Jill C.} and Bottoms, {Sidney F.} and Yelian, {Frank D.} and Cotton, {David B.}",
year = "1996",
month = "5",
language = "English (US)",
volume = "5",
pages = "128--131",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Brain natriuretic peptide and cyclic guanosine-3′,5′ monophosphate in pre-eclampsia

AU - Lauria, Michele R.

AU - Standley, Cynthia A

AU - Sorokin, Yoram

AU - Todt, Jill C.

AU - Bottoms, Sidney F.

AU - Yelian, Frank D.

AU - Cotton, David B.

PY - 1996/5

Y1 - 1996/5

N2 - The objective of this study is to determine the possibility that pre-eclampsia, a disease characterized by altered vascular tone, may result in altered levels of fetal BNP and cGMP, and to determine whether pre-eclampsia alters the maternal-fetal relationship of BNP and cGMP. Paired maternal and umbilical venous plasma levels of BNP and cGMP were determined in 13 pre-eclamptic and 9 normotensive primigravidas in the third trimester. Statistical analysis was performed using multivariate analysis of variance, linear regression, and canonical correlation. Overall, levels of cGMP were lower in pre-eclampsia (P < 0.03). Pre-eclampsia was also associated with an altered maternal-fetal relationship for BNP and cGMP (P < 0.008, P < 0.02, respectively). With pre-eclampsia, the maternal:fetal ratio was reduced for BNP and was increased for cGMP. Because of its role as a second messenger for many vasoactive hormones, we hypothesize that fetal cGMP levels may better reflect overall vascular tone than do individual hormones. Altered BNP and cGMP maternal-fetal homeostasis raises the possibility of maternal-fetal coordination of vascular control.

AB - The objective of this study is to determine the possibility that pre-eclampsia, a disease characterized by altered vascular tone, may result in altered levels of fetal BNP and cGMP, and to determine whether pre-eclampsia alters the maternal-fetal relationship of BNP and cGMP. Paired maternal and umbilical venous plasma levels of BNP and cGMP were determined in 13 pre-eclamptic and 9 normotensive primigravidas in the third trimester. Statistical analysis was performed using multivariate analysis of variance, linear regression, and canonical correlation. Overall, levels of cGMP were lower in pre-eclampsia (P < 0.03). Pre-eclampsia was also associated with an altered maternal-fetal relationship for BNP and cGMP (P < 0.008, P < 0.02, respectively). With pre-eclampsia, the maternal:fetal ratio was reduced for BNP and was increased for cGMP. Because of its role as a second messenger for many vasoactive hormones, we hypothesize that fetal cGMP levels may better reflect overall vascular tone than do individual hormones. Altered BNP and cGMP maternal-fetal homeostasis raises the possibility of maternal-fetal coordination of vascular control.

KW - Atrial natriuretic peptide

KW - Brain natriuretic peptide

KW - Cyclic guanosine-3′,5′ monophosphate

KW - Pre-eclampsia

UR - http://www.scopus.com/inward/record.url?scp=0029986169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029986169&partnerID=8YFLogxK

M3 - Article

C2 - 8796782

AN - SCOPUS:0029986169

VL - 5

SP - 128

EP - 131

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 3

ER -