Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

Annadurai Anandhan, Matthew Dodson, Cody J. Schmidlin, Pengfei Liu, Donna D. Zhang

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.

Original languageEnglish (US)
Pages (from-to)436-447
Number of pages12
JournalCell Chemical Biology
Volume27
Issue number4
DOIs
StatePublished - Apr 16 2020

Keywords

  • NRF2
  • cancer
  • cardiovascular disease
  • cell death
  • diabetes
  • ferritinophagy
  • ferroptosis
  • iron
  • lipid peroxidation
  • neurodegeneration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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