Breast cancer risk and genetic ancestry: A case-control study in Uruguay

Carolina Bonilla, Bernardo Bertoni, Pedro C. Hidalgo, Nora Artagaveytia, Elizabeth Ackermann, Isabel Barreto, Paula Cancela, Mónica Cappetta, Ana Egaña, Gonzalo Figueiro, Silvina Heinzen, Stanley Hooker, Estela Román, Mónica Sans, Rick A. Kittles

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Uruguay exhibits one of the highest rates of breast cancer in Latin America, similar to those of developed nations, the reasons for which are not completely understood. In this study we investigated the effect that ancestral background has on breast cancer susceptibility among Uruguayan women. Methods: We carried out a case-control study of 328 (164 cases, 164 controls) women enrolled in public hospitals and private clinics across the country. We estimated ancestral proportions using a panel of nuclear and mitochondrial ancestry informative markers (AIMs) and tested their association with breast cancer risk. Results: Nuclear individual ancestry in cases was (mean ± SD) 9.8 ± 7.6% African, 13.2 ± 10.2% Native American and 77.1 ± 13.1% European, and in controls 9.1 ± 7.5% African, 14.7 ± 11.2% Native American and 76.2 ± 14.2% European. There was no evidence of a difference in nuclear or mitochondrial ancestry between cases and controls. However, European mitochondrial haplogroup H was associated with breast cancer (OR = 2.0; 95% CI 1.1, 3.5). Conclusions: We have not found evidence that overall genetic ancestry differs between breast cancer patients and controls in Uruguay but we detected an association of the disease with a European mitochondrial lineage, which warrants further investigation.

Original languageEnglish (US)
Article number171
JournalBMC Women's Health
Volume15
Issue number1
DOIs
StatePublished - Feb 18 2015

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Keywords

  • Ancestry informative markers
  • Breast cancer
  • Latin America
  • Mitochondrial haplogroups
  • Population admixture
  • Uruguay

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Bonilla, C., Bertoni, B., Hidalgo, P. C., Artagaveytia, N., Ackermann, E., Barreto, I., Cancela, P., Cappetta, M., Egaña, A., Figueiro, G., Heinzen, S., Hooker, S., Román, E., Sans, M., & Kittles, R. A. (2015). Breast cancer risk and genetic ancestry: A case-control study in Uruguay. BMC Women's Health, 15(1), [171]. https://doi.org/10.1186/s12905-015-0171-8