Breast-feeding in the management of the newborn with phenylketonuria: A practical approach to dietary therapy

Linda C. Greve, Mark D Wheeler, Dayna K. Green-Burgeson, Elinor M. Zorn

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Guidelines introduced in 1979 for breast-feeding infants with phenylketonuria included a formula containing low amounts of phenylalanine (PHE) as part of the dietary prescription. Although the guidelines were revised in 1988, new PHE-free products were not included. In addition, the guidelines recommend infant weight checks before and after feeding to ensure correct dietary intake of breast milk. In this study, we present data based on treatment of 13 infants for the first 6 months of life using a PHE-free product and human milk (n=9) or commercial formula (n=4). The study began with nine breast-fed infants; five were weaned before 6 months of age and were discontinued from the study. Published estimates of volume and energy of daily human milk consumption were used to prescribe and assess intake of breast milk. No differences were noted between the groups in blood levels of PHE at initiation of dietary therapy, age at initiation of dietary therapy, or length of time to achieve metabolic control. Furthermore, blood levels of PHE and growth parameters for each month up to 6 months of age were similar for both groups. These data support the efficacy of PHE-free formula and estimation of breast milk volumes in managing the diet of infants with phenylketonuria.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalJournal of the American Dietetic Association
Volume94
Issue number3
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

phenylketonuria
diet therapy
Phenylketonurias
breast feeding
Breast Feeding
Phenylalanine
phenylalanine
Human Milk
breast milk
neonates
Newborn Infant
Guidelines
Therapeutics
milk consumption
blood groups
Blood Group Antigens
breasts
Prescriptions
food intake
Breast

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Breast-feeding in the management of the newborn with phenylketonuria : A practical approach to dietary therapy. / Greve, Linda C.; Wheeler, Mark D; Green-Burgeson, Dayna K.; Zorn, Elinor M.

In: Journal of the American Dietetic Association, Vol. 94, No. 3, 01.01.1994, p. 305-309.

Research output: Contribution to journalArticle

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