Brief Report: The Prevalence of Neurofibromatosis Type 1 among Children with Autism Spectrum Disorder Identified by the Autism and Developmental Disabilities Monitoring Network

Deborah A. Bilder, Amanda V. Bakian, David A. Stevenson, Paul S. Carbone, Christopher Cunniff, Alyson B. Goodman, William M. McMahon, Nicole P. Fisher, David Viskochil

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). The frequency of ASD/NF1 co-occurrence has been subject to debate since the 1980s. This relationship was investigated in a large population-based sample of 8-year-old children identified with ASD (N = 12,271) by the Centers for Disease Control and Prevention’s Autism and Developmental Disabilities Monitoring (ADDM) Network. Twenty-two (1-in-558) children with ASD had diagnosed NF1, exceeding NF1 general population estimates by four to five fold. Children with ASD/NF1 versus ASD without NF1 were significantly less likely to receive a community-based ASD diagnosis (p = 0.04) and understand non-verbal communication (p = 0.001). These findings underscore the importance of including social-communication ability among relevant developmental concerns in children with NF1.

Original languageEnglish (US)
Pages (from-to)3369-3376
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume46
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Autism
  • Children
  • Developmental disabilities
  • Neurofibromatosis
  • Non-verbal communications

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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