Brief Report: The Prevalence of Neurofibromatosis Type 1 among Children with Autism Spectrum Disorder Identified by the Autism and Developmental Disabilities Monitoring Network

Deborah A. Bilder, Amanda V. Bakian, David A. Stevenson, Paul S. Carbone, Christopher M Cunniff, Alyson B. Goodman, William M. McMahon, Nicole P. Fisher, David Viskochil

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). The frequency of ASD/NF1 co-occurrence has been subject to debate since the 1980s. This relationship was investigated in a large population-based sample of 8-year-old children identified with ASD (N = 12,271) by the Centers for Disease Control and Prevention’s Autism and Developmental Disabilities Monitoring (ADDM) Network. Twenty-two (1-in-558) children with ASD had diagnosed NF1, exceeding NF1 general population estimates by four to five fold. Children with ASD/NF1 versus ASD without NF1 were significantly less likely to receive a community-based ASD diagnosis (p = 0.04) and understand non-verbal communication (p = 0.001). These findings underscore the importance of including social-communication ability among relevant developmental concerns in children with NF1.

Original languageEnglish (US)
Pages (from-to)3369-3376
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume46
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Developmental Disabilities
Neurofibromatosis 1
Autistic Disorder
Communication
Neurocutaneous Syndromes
Autism Spectrum Disorder
Centers for Disease Control and Prevention (U.S.)
Population

Keywords

  • Autism
  • Children
  • Developmental disabilities
  • Neurofibromatosis
  • Non-verbal communications

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Brief Report : The Prevalence of Neurofibromatosis Type 1 among Children with Autism Spectrum Disorder Identified by the Autism and Developmental Disabilities Monitoring Network. / Bilder, Deborah A.; Bakian, Amanda V.; Stevenson, David A.; Carbone, Paul S.; Cunniff, Christopher M; Goodman, Alyson B.; McMahon, William M.; Fisher, Nicole P.; Viskochil, David.

In: Journal of Autism and Developmental Disorders, Vol. 46, No. 10, 01.10.2016, p. 3369-3376.

Research output: Contribution to journalArticle

Bilder, Deborah A. ; Bakian, Amanda V. ; Stevenson, David A. ; Carbone, Paul S. ; Cunniff, Christopher M ; Goodman, Alyson B. ; McMahon, William M. ; Fisher, Nicole P. ; Viskochil, David. / Brief Report : The Prevalence of Neurofibromatosis Type 1 among Children with Autism Spectrum Disorder Identified by the Autism and Developmental Disabilities Monitoring Network. In: Journal of Autism and Developmental Disorders. 2016 ; Vol. 46, No. 10. pp. 3369-3376.
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