Broad range analysis of endocrine disruptors and pharmaceuticals using gas chromatography and liquid chromatography tandem mass spectrometry

Rebecca A. Trenholm, Brett J. Vanderford, Janie C. Holady, David J. Rexing, Shane A. Snyder

Research output: Contribution to journalArticlepeer-review

184 Scopus citations

Abstract

Endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) have been globally detected in impacted natural waters. The detection of trace quantities of EDCs and PPCPs in the environment is of great concern since some of these compounds have known physiological responses at low concentrations. EDCs can have a wide range of polarities, acidic and basic moieties, and exist in trace quantities, which often requires numerous complex extractions, large sample collection volumes, and multiple instrumental analyses. A comprehensive method has been developed allowing for the analysis of 58 potential EDCs in various water matrices using a single solid-phase extraction (SPE) of a 1 L sample with subsequent analyses using both gas chromatography and liquid chromatography, each coupled with tandem mass spectrometry (GC-MS/MS and LC-MS/MS). Instrument detection limits ranged between 0.12-7.5 pg with corresponding method reporting limits of 1-10 ng l-1 in water. Recoveries for most compounds were between 50% and 112% with good reproducibility (RSD 6-22%).

Original languageEnglish (US)
Pages (from-to)1990-1998
Number of pages9
JournalChemosphere
Volume65
Issue number11
DOIs
StatePublished - Dec 2006
Externally publishedYes

Keywords

  • Endocrine disruptor
  • GC-MS/MS
  • LC-MS/MS
  • Solid-phase extraction

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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