Brugada syndrome: From cell to bedside

Charles Antzelevitch, Pedro Brugada, Josep Brugada, Ramon Brugada, Shahbudin H. Rahimtoola, Joseph S. Alpert, Robert O. Bonow, Bernard J. Gersh, Robert A. O'Rourke, Melvin M. Scheinman, Sidney C. Smith

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

Since its introduction as a new clinical entity in 1992, the Brugada syndrome has attracted great interest because of its high incidence in many parts of the world and its association with high risk for sudden death in infants, children, and young adults. Recent years have witnessed an exponential rise in the number of reported cases and a striking proliferation of articles serving to define the clinical, genetic, cellular, ionic, and molecular aspects of the disease. A consensus report published in 2002 delineated diagnostic criteria for the syndrome. A second consensus conference was held in September 2003. This review provides an in-depth overview of the clinical, genetic, molecular, and cellular aspects of the Brugada syndrome, incorporating the results of the two consensus conferences, and the numerous clinical and basic publications on the subject. The proposed terminology, diagnostic criteria, risk stratification schemes, and device and pharmacologic approach to therapy discussed are based on available clinical and basic studies and should be considered a work-in-progress that will without doubt require fine-tuning as confirmatory data from molecular studies and prospective trials become available.

Original languageEnglish (US)
Pages (from-to)9-54
Number of pages46
JournalCurrent Problems in Cardiology
Volume30
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Antzelevitch, C., Brugada, P., Brugada, J., Brugada, R., Rahimtoola, S. H., Alpert, J. S., Bonow, R. O., Gersh, B. J., O'Rourke, R. A., Scheinman, M. M., & Smith, S. C. (2005). Brugada syndrome: From cell to bedside. Current Problems in Cardiology, 30(1), 9-54. https://doi.org/10.1016/S0146-2806(04)00216-6