Burden of Alzheimer's disease and association with negative health outcomes

Daniel C Malone, Trent P. McLaughlin, Peter M. Wahl, Christopher Leibman, H. Michael Arrighi, Mark J. Cziraky, Lisa M. Mucha

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: To examine the association of Alzheimer's disease (AD) with common chronic conditions, acute care events, and risk of hospitalization. Study Design: Retrospective matched cohort analysis. Methods: Community-dwelling subjects with a diagnosis of and/or medication for AD were matched to subjects without AD based on age, sex, and geographic region. Administrative claims from commercially insured health plans for medical and pharmacy services provided from January 1, 2000, to March 31, 2006 (inclusive) were analyzed.The Deyo Charlson Index (DCI) was used to assess the number of chronic conditions.The outcomes of interest were risk of fractures and hospitalization. Results: Among 5396 persons with AD and a matched cohort of 5396 persons without the condition, subjects with AD were more likely to have a diagnosis for any of the DCI components, had a higher rate of fractures (17.7% vs 7.9%, P <.00) and other urgent medical events (eg, pneumonia 14.0% vs 6.3%, P <.00), and were more likely to be hospitalized (odds ratio = 1.7; 95% confidence interval = 1.5, 1.9). There were significant differences in the medication use between the 2 groups, with the use of psychotics/tranquilizers 9-fold higher among persons with AD. Conclusion: Persons with AD have higher odds of experiencing a fracture, being hospitalized, and requiring other acute care medical services than those without AD. The disease also is associated with a higher prevalence of common chronic conditions.

Original languageEnglish (US)
Pages (from-to)481-488
Number of pages8
JournalAmerican Journal of Managed Care
Volume15
Issue number8
StatePublished - Aug 2009

Fingerprint

Alzheimer Disease
Health
Hospitalization
Independent Living
Pharmaceutical Services
Pneumonia
Cohort Studies
Retrospective Studies
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Health Policy

Cite this

Malone, D. C., McLaughlin, T. P., Wahl, P. M., Leibman, C., Arrighi, H. M., Cziraky, M. J., & Mucha, L. M. (2009). Burden of Alzheimer's disease and association with negative health outcomes. American Journal of Managed Care, 15(8), 481-488.

Burden of Alzheimer's disease and association with negative health outcomes. / Malone, Daniel C; McLaughlin, Trent P.; Wahl, Peter M.; Leibman, Christopher; Arrighi, H. Michael; Cziraky, Mark J.; Mucha, Lisa M.

In: American Journal of Managed Care, Vol. 15, No. 8, 08.2009, p. 481-488.

Research output: Contribution to journalArticle

Malone, DC, McLaughlin, TP, Wahl, PM, Leibman, C, Arrighi, HM, Cziraky, MJ & Mucha, LM 2009, 'Burden of Alzheimer's disease and association with negative health outcomes', American Journal of Managed Care, vol. 15, no. 8, pp. 481-488.
Malone DC, McLaughlin TP, Wahl PM, Leibman C, Arrighi HM, Cziraky MJ et al. Burden of Alzheimer's disease and association with negative health outcomes. American Journal of Managed Care. 2009 Aug;15(8):481-488.
Malone, Daniel C ; McLaughlin, Trent P. ; Wahl, Peter M. ; Leibman, Christopher ; Arrighi, H. Michael ; Cziraky, Mark J. ; Mucha, Lisa M. / Burden of Alzheimer's disease and association with negative health outcomes. In: American Journal of Managed Care. 2009 ; Vol. 15, No. 8. pp. 481-488.
@article{f42f73bf9f2349feab1c416d8f571158,
title = "Burden of Alzheimer's disease and association with negative health outcomes",
abstract = "Objective: To examine the association of Alzheimer's disease (AD) with common chronic conditions, acute care events, and risk of hospitalization. Study Design: Retrospective matched cohort analysis. Methods: Community-dwelling subjects with a diagnosis of and/or medication for AD were matched to subjects without AD based on age, sex, and geographic region. Administrative claims from commercially insured health plans for medical and pharmacy services provided from January 1, 2000, to March 31, 2006 (inclusive) were analyzed.The Deyo Charlson Index (DCI) was used to assess the number of chronic conditions.The outcomes of interest were risk of fractures and hospitalization. Results: Among 5396 persons with AD and a matched cohort of 5396 persons without the condition, subjects with AD were more likely to have a diagnosis for any of the DCI components, had a higher rate of fractures (17.7{\%} vs 7.9{\%}, P <.00) and other urgent medical events (eg, pneumonia 14.0{\%} vs 6.3{\%}, P <.00), and were more likely to be hospitalized (odds ratio = 1.7; 95{\%} confidence interval = 1.5, 1.9). There were significant differences in the medication use between the 2 groups, with the use of psychotics/tranquilizers 9-fold higher among persons with AD. Conclusion: Persons with AD have higher odds of experiencing a fracture, being hospitalized, and requiring other acute care medical services than those without AD. The disease also is associated with a higher prevalence of common chronic conditions.",
author = "Malone, {Daniel C} and McLaughlin, {Trent P.} and Wahl, {Peter M.} and Christopher Leibman and Arrighi, {H. Michael} and Cziraky, {Mark J.} and Mucha, {Lisa M.}",
year = "2009",
month = "8",
language = "English (US)",
volume = "15",
pages = "481--488",
journal = "American Journal of Managed Care",
issn = "1088-0224",
publisher = "Ascend Media",
number = "8",

}

TY - JOUR

T1 - Burden of Alzheimer's disease and association with negative health outcomes

AU - Malone, Daniel C

AU - McLaughlin, Trent P.

AU - Wahl, Peter M.

AU - Leibman, Christopher

AU - Arrighi, H. Michael

AU - Cziraky, Mark J.

AU - Mucha, Lisa M.

PY - 2009/8

Y1 - 2009/8

N2 - Objective: To examine the association of Alzheimer's disease (AD) with common chronic conditions, acute care events, and risk of hospitalization. Study Design: Retrospective matched cohort analysis. Methods: Community-dwelling subjects with a diagnosis of and/or medication for AD were matched to subjects without AD based on age, sex, and geographic region. Administrative claims from commercially insured health plans for medical and pharmacy services provided from January 1, 2000, to March 31, 2006 (inclusive) were analyzed.The Deyo Charlson Index (DCI) was used to assess the number of chronic conditions.The outcomes of interest were risk of fractures and hospitalization. Results: Among 5396 persons with AD and a matched cohort of 5396 persons without the condition, subjects with AD were more likely to have a diagnosis for any of the DCI components, had a higher rate of fractures (17.7% vs 7.9%, P <.00) and other urgent medical events (eg, pneumonia 14.0% vs 6.3%, P <.00), and were more likely to be hospitalized (odds ratio = 1.7; 95% confidence interval = 1.5, 1.9). There were significant differences in the medication use between the 2 groups, with the use of psychotics/tranquilizers 9-fold higher among persons with AD. Conclusion: Persons with AD have higher odds of experiencing a fracture, being hospitalized, and requiring other acute care medical services than those without AD. The disease also is associated with a higher prevalence of common chronic conditions.

AB - Objective: To examine the association of Alzheimer's disease (AD) with common chronic conditions, acute care events, and risk of hospitalization. Study Design: Retrospective matched cohort analysis. Methods: Community-dwelling subjects with a diagnosis of and/or medication for AD were matched to subjects without AD based on age, sex, and geographic region. Administrative claims from commercially insured health plans for medical and pharmacy services provided from January 1, 2000, to March 31, 2006 (inclusive) were analyzed.The Deyo Charlson Index (DCI) was used to assess the number of chronic conditions.The outcomes of interest were risk of fractures and hospitalization. Results: Among 5396 persons with AD and a matched cohort of 5396 persons without the condition, subjects with AD were more likely to have a diagnosis for any of the DCI components, had a higher rate of fractures (17.7% vs 7.9%, P <.00) and other urgent medical events (eg, pneumonia 14.0% vs 6.3%, P <.00), and were more likely to be hospitalized (odds ratio = 1.7; 95% confidence interval = 1.5, 1.9). There were significant differences in the medication use between the 2 groups, with the use of psychotics/tranquilizers 9-fold higher among persons with AD. Conclusion: Persons with AD have higher odds of experiencing a fracture, being hospitalized, and requiring other acute care medical services than those without AD. The disease also is associated with a higher prevalence of common chronic conditions.

UR - http://www.scopus.com/inward/record.url?scp=69749104112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69749104112&partnerID=8YFLogxK

M3 - Article

C2 - 19670951

AN - SCOPUS:69749104112

VL - 15

SP - 481

EP - 488

JO - American Journal of Managed Care

JF - American Journal of Managed Care

SN - 1088-0224

IS - 8

ER -