Burkitt's-like lymphoma of T-cell type.

J. D. Oliver, T. M. Grogan, C. M. Payne, Catherine S Perry, L. C. Richter, C. S. Rangel

Research output: Contribution to journalArticle

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Abstract

Over an 8-yr period, we studied 29 cases of Burkitt's/Burkitt's-like lymphoma and unexpectedly found 2 Burkitt's-like cases of the T-cell type. One case presented as diffuse adenopathy in a 35-yr-old male. A second case presented as a jaw mass in a 2-yr-old girl with Down's syndrome. Histologically, each case demonstrated usual Burkitt's-like morphology (intermediate-size cells with high nuclear/cytoplasmic ratio, 1 to 3 prominent nucleoli, high mitotic rate, basophilic cytoplasm, and cytoplasmic vacuolation). Ultrastructural morphometric data corroborated the Burkitt's-like nature of these neoplasms. Immunologically, the neoplasms were of "novel" T-cell phenotype, as seen in peripheral T-cell lymphoma (PTL). The cases showed variable expression of activation antigens (e.g., Ia) and weak to moderate expression of proliferation antigens as measured by Ki-67. This modest proliferative activity (less than 25% Ki-67 expression) contrasts with Burkitt's-like lymphomas of the B-cell type which usually show greater than 80% Ki-67 expression. The jaw tumor also demonstrated positivity for human progenitor cell antigen (HPCA) as commonly found in leukemia. Both cases mimic granulocytic sarcoma by virtue of their eosinophilic/myelocytic recruitment--a phenomenon previously reported in association with PTL. The patients have survived 62 wk and 20 wk, respectively, surpassing the survival rates seen in our concurrent B-cell Burkitt's-like lymphomas (12 wk). Burkitt's-like lymphoma of the T-cell type appears to be a distinctive immunological subset of potential clinical and prognostic relevance.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalModern Pathology
Volume1
Issue number1
StatePublished - Jan 1988

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Burkitt Lymphoma
Peripheral T-Cell Lymphoma
T-Lymphocytes
Jaw
Myeloid Sarcoma
Antigens
Neoplasms
Histocompatibility Antigens Class II
B-Cell Lymphoma
Down Syndrome
Cell Size
Cytoplasm
Leukemia
B-Lymphocytes
Stem Cells
Survival Rate
Phenotype

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Oliver, J. D., Grogan, T. M., Payne, C. M., Perry, C. S., Richter, L. C., & Rangel, C. S. (1988). Burkitt's-like lymphoma of T-cell type. Modern Pathology, 1(1), 15-22.

Burkitt's-like lymphoma of T-cell type. / Oliver, J. D.; Grogan, T. M.; Payne, C. M.; Perry, Catherine S; Richter, L. C.; Rangel, C. S.

In: Modern Pathology, Vol. 1, No. 1, 01.1988, p. 15-22.

Research output: Contribution to journalArticle

Oliver, JD, Grogan, TM, Payne, CM, Perry, CS, Richter, LC & Rangel, CS 1988, 'Burkitt's-like lymphoma of T-cell type.', Modern Pathology, vol. 1, no. 1, pp. 15-22.
Oliver JD, Grogan TM, Payne CM, Perry CS, Richter LC, Rangel CS. Burkitt's-like lymphoma of T-cell type. Modern Pathology. 1988 Jan;1(1):15-22.
Oliver, J. D. ; Grogan, T. M. ; Payne, C. M. ; Perry, Catherine S ; Richter, L. C. ; Rangel, C. S. / Burkitt's-like lymphoma of T-cell type. In: Modern Pathology. 1988 ; Vol. 1, No. 1. pp. 15-22.
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