Calcium, vitamin D, and risk of adenoma recurrence (United States)

María Elena Martínez, James R. Marshall, Richard Sampliner, Jody Wilkinson, David S Alberts

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective: Few data exist regarding the association between calcium intake and adenoma recurrence, and no data exist for vitamin D. We investigated the role of dietary and supplemental sources of calcium and vitamin D in the etiology of adenoma recurrence. Methods: Analyses were conducted among 1304 male and female participants in the Wheat Bran Fiber (WBF) trial of adenoma recurrence. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: In the fully adjusted multivariate model, the OR for participants with dietary calcium intake above 1068 versus those with intake below 698 mg/day was 0.56 (95% CI = 0.39-0.80; p-trend = 0.007). Calcium supplementation at doses above 200 mg/day did not affect risk of recurrence. Although a borderline inverse association between dietary vitamin D and recurrence was observed after adjustment for age and gender, the association weakened in the fully adjusted model (OR = 0.78 for individuals in the upper compared to the lower quartile; 95% CI = 0.54-1.13). No association was shown for supplemental sources of vitamin D. Conclusions: Results of this study indicate that a higher intake of calcium decreases the risk of adenoma recurrence by approximately 45%, whereas vitamin D has no significant effect on recurrence rates.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalCancer Causes and Control
Volume13
Issue number3
DOIs
StatePublished - 2002

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Vitamin D
Adenoma
Calcium
Recurrence
Odds Ratio
Confidence Intervals
Dietary Calcium
Dietary Fiber
Logistic Models

Keywords

  • Adenoma recurrence
  • Calcium
  • Colorectal adenoma
  • Vitamin D

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Calcium, vitamin D, and risk of adenoma recurrence (United States). / Martínez, María Elena; Marshall, James R.; Sampliner, Richard; Wilkinson, Jody; Alberts, David S.

In: Cancer Causes and Control, Vol. 13, No. 3, 2002, p. 213-220.

Research output: Contribution to journalArticle

Martínez, ME, Marshall, JR, Sampliner, R, Wilkinson, J & Alberts, DS 2002, 'Calcium, vitamin D, and risk of adenoma recurrence (United States)', Cancer Causes and Control, vol. 13, no. 3, pp. 213-220. https://doi.org/10.1023/A:1015032215779
Martínez, María Elena ; Marshall, James R. ; Sampliner, Richard ; Wilkinson, Jody ; Alberts, David S. / Calcium, vitamin D, and risk of adenoma recurrence (United States). In: Cancer Causes and Control. 2002 ; Vol. 13, No. 3. pp. 213-220.
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