Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: The Africa America Diabetes Mellitus (AADM) Study

Yuanxiu Chen, Rick Kittles, Jie Zhou, Guanjie Chen, Adebowale Adeyemo, Ramesh K. Panguluri, Weidong Chen, Albert Amoah, Victoria Opoku, Joseph Acheampong, Kofi Agyenim-Boateng, Benjamin Ackon Eghan, Awuah Nyantaki, Johnnie Oli, Godfrey Okafor, Esther Ofoegbu, Babatunde Osotimehin, Fayeofori Abbiyesuku, Thomas Johnson, Olufemi FasanmadeTheresa Rufus, Paulette Furbert-Harris, Harold I. Daniel, Kate A. Berg, Francis S. Collins, Georgia M. Dunston, Charles N. Rotimi

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

To investigate whether the three single nucleotide polymorphisms (SNPs), SNP-43, -56, and -63 of CAPN10 were associated with type 2 diabetes in a West African cohort. A total of 347 diabetic subjects and 148 unaffected controls from four ethnic groups in two West African countries were enrolled in this study. After genotyping three SNPs of CAPN10 and one SNP from CYP19, the allele, genotype, and haplotype frequencies as well as the odds ratios were calculated to test their association with type 2 diabetes. None of the alleles or genotypes was associated with type 2 diabetes. Although statistical analysis indicated that haplotype 221 was associated with type 2 diabetes (OR, 3.765; 95% CI, 1.577-8.989) in the two ethnic groups of Nigeria, the same haplotype did not show any association with type 2 diabetes in the two ethnic groups in Ghana (OR, 0.906; 95% CI, 0.322-2.552). Considering the relatively low frequency of haplotype 221 and that none of the haplotypes including 221 was associated with any of the diabetes-related quantitative traits tested, it is concluded that SNP-43, -56, and -63 of the CAPN10 gene variants may play a limited role in the risk of type 2 diabetes risks in this cohort of West Africans.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalAnnals of epidemiology
Volume15
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Keywords

  • Calpain-10
  • Insulin
  • SNP-43
  • Type 2 Diabetes
  • West Africa

ASJC Scopus subject areas

  • Epidemiology

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