Can structural joint damage measured with mr imaging be used to predict knee replacement in the following year?

Frank W. Roemer, Chian K Kwoh, Michael J. Hannon, David J. Hunter, Felix Eckstein, Zhijie Wang, Robert M. Boudreau, Markus R. John, Michael C. Nevitt, Ali Guermazi

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Abstract

Purpose: To assess whether magnetic resonance (MR) imaging-based cross-sectional measures of structural joint damage can be used to predict knee replacement during the following year. Materials and Methods: Participants were drawn from the Osteoarthritis Initiative, a longitudinal observational study that includes 4796 participants who have knee osteoarthritis or are at risk. The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informed consent was obtained from all participants. During the 5 years of follow-up, 199 knees underwent knee replacement and were matched with 199 control knees that did not undergo knee replacement. Knees were matched according to radiographic disease stage and patient sex and age. All knees that underwent knee replacement and had MR images available from the year before surgery were included. MR images were assessed for cartilage damage, bone marrow lesions, meniscal damage, meniscal extrusion, synovitis, and effusion prior to reported knee replacement. Conditional logistic regression was applied to assess the risk of knee replacement. Analyses were performed on a compartmental and knee level.. Results: Participants had a mean age ± standard deviation of 64.2 years ± 8.4 (range, 47-82 years) and were predominantly women (232 of 398 participants, 58.3%). Risk for knee replacement was significantly increased for knees that exhibited two or more subregions with severe cartilage loss (odds ratio [OR], 16.5; 95% confidence interval [CI]: 3.96, 68.76), more than two subregions with bone marrow lesions (OR, 4.00; 95% CI: 1.75, 9.16), medial meniscal maceration (OR, 1.84; 95% CI: 1.13, 2.99), effusion (OR, 4.75; 95% CI: 2.55, 8.85), or synovitis (OR, 2.17; 95% CI: 1.33, 3.56), but not extrusion (OR, 1.00; 95% CI: 0.60,1.67), when compared with knees that did not exhibit these features as the reference standard.. Conclusion: Apart from meniscal extrusion, all features of tissue abnormalities at MR imaging were related to clinical prognosis and could be used to predict knee replacement in the following year..

Original languageEnglish (US)
Pages (from-to)810-820
Number of pages11
JournalRadiology
Volume274
Issue number3
DOIs
StatePublished - Mar 1 2015

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Knee
Joints
Odds Ratio
Confidence Intervals
Synovitis
Cartilage
Magnetic Resonance Spectroscopy
Bone Marrow
Magnetic Resonance Imaging
Health Insurance Portability and Accountability Act
Knee Osteoarthritis
Research Ethics Committees
Informed Consent
Osteoarthritis
Observational Studies
Longitudinal Studies
Logistic Models

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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Can structural joint damage measured with mr imaging be used to predict knee replacement in the following year? / Roemer, Frank W.; Kwoh, Chian K; Hannon, Michael J.; Hunter, David J.; Eckstein, Felix; Wang, Zhijie; Boudreau, Robert M.; John, Markus R.; Nevitt, Michael C.; Guermazi, Ali.

In: Radiology, Vol. 274, No. 3, 01.03.2015, p. 810-820.

Research output: Contribution to journalArticle

Roemer, FW, Kwoh, CK, Hannon, MJ, Hunter, DJ, Eckstein, F, Wang, Z, Boudreau, RM, John, MR, Nevitt, MC & Guermazi, A 2015, 'Can structural joint damage measured with mr imaging be used to predict knee replacement in the following year?', Radiology, vol. 274, no. 3, pp. 810-820. https://doi.org/10.1148/radiol.14140991
Roemer, Frank W. ; Kwoh, Chian K ; Hannon, Michael J. ; Hunter, David J. ; Eckstein, Felix ; Wang, Zhijie ; Boudreau, Robert M. ; John, Markus R. ; Nevitt, Michael C. ; Guermazi, Ali. / Can structural joint damage measured with mr imaging be used to predict knee replacement in the following year?. In: Radiology. 2015 ; Vol. 274, No. 3. pp. 810-820.
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abstract = "Purpose: To assess whether magnetic resonance (MR) imaging-based cross-sectional measures of structural joint damage can be used to predict knee replacement during the following year. Materials and Methods: Participants were drawn from the Osteoarthritis Initiative, a longitudinal observational study that includes 4796 participants who have knee osteoarthritis or are at risk. The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informed consent was obtained from all participants. During the 5 years of follow-up, 199 knees underwent knee replacement and were matched with 199 control knees that did not undergo knee replacement. Knees were matched according to radiographic disease stage and patient sex and age. All knees that underwent knee replacement and had MR images available from the year before surgery were included. MR images were assessed for cartilage damage, bone marrow lesions, meniscal damage, meniscal extrusion, synovitis, and effusion prior to reported knee replacement. Conditional logistic regression was applied to assess the risk of knee replacement. Analyses were performed on a compartmental and knee level.. Results: Participants had a mean age ± standard deviation of 64.2 years ± 8.4 (range, 47-82 years) and were predominantly women (232 of 398 participants, 58.3{\%}). Risk for knee replacement was significantly increased for knees that exhibited two or more subregions with severe cartilage loss (odds ratio [OR], 16.5; 95{\%} confidence interval [CI]: 3.96, 68.76), more than two subregions with bone marrow lesions (OR, 4.00; 95{\%} CI: 1.75, 9.16), medial meniscal maceration (OR, 1.84; 95{\%} CI: 1.13, 2.99), effusion (OR, 4.75; 95{\%} CI: 2.55, 8.85), or synovitis (OR, 2.17; 95{\%} CI: 1.33, 3.56), but not extrusion (OR, 1.00; 95{\%} CI: 0.60,1.67), when compared with knees that did not exhibit these features as the reference standard.. Conclusion: Apart from meniscal extrusion, all features of tissue abnormalities at MR imaging were related to clinical prognosis and could be used to predict knee replacement in the following year..",
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AU - Roemer, Frank W.

AU - Kwoh, Chian K

AU - Hannon, Michael J.

AU - Hunter, David J.

AU - Eckstein, Felix

AU - Wang, Zhijie

AU - Boudreau, Robert M.

AU - John, Markus R.

AU - Nevitt, Michael C.

AU - Guermazi, Ali

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N2 - Purpose: To assess whether magnetic resonance (MR) imaging-based cross-sectional measures of structural joint damage can be used to predict knee replacement during the following year. Materials and Methods: Participants were drawn from the Osteoarthritis Initiative, a longitudinal observational study that includes 4796 participants who have knee osteoarthritis or are at risk. The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informed consent was obtained from all participants. During the 5 years of follow-up, 199 knees underwent knee replacement and were matched with 199 control knees that did not undergo knee replacement. Knees were matched according to radiographic disease stage and patient sex and age. All knees that underwent knee replacement and had MR images available from the year before surgery were included. MR images were assessed for cartilage damage, bone marrow lesions, meniscal damage, meniscal extrusion, synovitis, and effusion prior to reported knee replacement. Conditional logistic regression was applied to assess the risk of knee replacement. Analyses were performed on a compartmental and knee level.. Results: Participants had a mean age ± standard deviation of 64.2 years ± 8.4 (range, 47-82 years) and were predominantly women (232 of 398 participants, 58.3%). Risk for knee replacement was significantly increased for knees that exhibited two or more subregions with severe cartilage loss (odds ratio [OR], 16.5; 95% confidence interval [CI]: 3.96, 68.76), more than two subregions with bone marrow lesions (OR, 4.00; 95% CI: 1.75, 9.16), medial meniscal maceration (OR, 1.84; 95% CI: 1.13, 2.99), effusion (OR, 4.75; 95% CI: 2.55, 8.85), or synovitis (OR, 2.17; 95% CI: 1.33, 3.56), but not extrusion (OR, 1.00; 95% CI: 0.60,1.67), when compared with knees that did not exhibit these features as the reference standard.. Conclusion: Apart from meniscal extrusion, all features of tissue abnormalities at MR imaging were related to clinical prognosis and could be used to predict knee replacement in the following year..

AB - Purpose: To assess whether magnetic resonance (MR) imaging-based cross-sectional measures of structural joint damage can be used to predict knee replacement during the following year. Materials and Methods: Participants were drawn from the Osteoarthritis Initiative, a longitudinal observational study that includes 4796 participants who have knee osteoarthritis or are at risk. The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informed consent was obtained from all participants. During the 5 years of follow-up, 199 knees underwent knee replacement and were matched with 199 control knees that did not undergo knee replacement. Knees were matched according to radiographic disease stage and patient sex and age. All knees that underwent knee replacement and had MR images available from the year before surgery were included. MR images were assessed for cartilage damage, bone marrow lesions, meniscal damage, meniscal extrusion, synovitis, and effusion prior to reported knee replacement. Conditional logistic regression was applied to assess the risk of knee replacement. Analyses were performed on a compartmental and knee level.. Results: Participants had a mean age ± standard deviation of 64.2 years ± 8.4 (range, 47-82 years) and were predominantly women (232 of 398 participants, 58.3%). Risk for knee replacement was significantly increased for knees that exhibited two or more subregions with severe cartilage loss (odds ratio [OR], 16.5; 95% confidence interval [CI]: 3.96, 68.76), more than two subregions with bone marrow lesions (OR, 4.00; 95% CI: 1.75, 9.16), medial meniscal maceration (OR, 1.84; 95% CI: 1.13, 2.99), effusion (OR, 4.75; 95% CI: 2.55, 8.85), or synovitis (OR, 2.17; 95% CI: 1.33, 3.56), but not extrusion (OR, 1.00; 95% CI: 0.60,1.67), when compared with knees that did not exhibit these features as the reference standard.. Conclusion: Apart from meniscal extrusion, all features of tissue abnormalities at MR imaging were related to clinical prognosis and could be used to predict knee replacement in the following year..

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