Abstract
Objective: Does supplemental perioperative oxygen reduce the risk of surgical wound infection after colorectal surgery? Design: Randomized controlled trial. Setting: Multicentre trial that included 14 hospitals in Spain. Patients: 300 patients aged 18-80 years who underwent elective colorectal resection. Patients who had surgery performed laparoscopically or who had minor colon surgery were excluded. Intervention: Patients were randomly allocated to either 30% or 80% fraction of inspired oxygen (FiO2) intraoperatively and for 6 hours postoperatively. Anesthetic treatment and antibiotic administration were standardized. Main Outcome Measure: Surgical site infection (SSI) as defined by the Center for Disease Control. Results: SSI occurred in 35 of 143 patients (24.4%) who were administered 30% Fio2 and in 22 of 148 patients (14.9%) who were administered 80% FiO2 (p = 0.04). The risk of SSI was 39% lower in the 80% group (relative risk [RR], 0.61; 95% confidence interval [CI], 0.38-0.98) versus the 30% FiO2 group. Conclusions: Patients receiving supplemental oxygen have a significant reduction in risk of surgical site infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-216 |
| Number of pages | 3 |
| Journal | Canadian Journal of Surgery |
| Volume | 50 |
| Issue number | 3 |
| State | Published - Jun 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Canadian association of general surgeons and American college of surgeons evidence based reviews in surgery. 21. the risk of surgical site infection is reduced with perioperative oxygen. / Brasel, Karen; McRitchie, Donna; Dellinger, Patch; Barkun, J. S T; Brasel, K.; Cogbill, T.; Cutter, S.; Fitzgerald, G. W N; Henteleff, H. J A; Kirkpatrick, A. W.; Latosinsky, S.; Macleon, A.; MacRae, H. M.; Mastracci, T. M.; McLeod, R. S.; Neumayer, Leigh A; Smith, S.; Taylor, M. C.; McKenzie, M. E.
In: Canadian Journal of Surgery, Vol. 50, No. 3, 06.2007, p. 214-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Canadian association of general surgeons and American college of surgeons evidence based reviews in surgery. 21. the risk of surgical site infection is reduced with perioperative oxygen
AU - Brasel, Karen
AU - McRitchie, Donna
AU - Dellinger, Patch
AU - Barkun, J. S T
AU - Brasel, K.
AU - Cogbill, T.
AU - Cutter, S.
AU - Fitzgerald, G. W N
AU - Henteleff, H. J A
AU - Kirkpatrick, A. W.
AU - Latosinsky, S.
AU - Macleon, A.
AU - MacRae, H. M.
AU - Mastracci, T. M.
AU - McLeod, R. S.
AU - Neumayer, Leigh A
AU - Smith, S.
AU - Taylor, M. C.
AU - McKenzie, M. E.
PY - 2007/6
Y1 - 2007/6
N2 - Objective: Does supplemental perioperative oxygen reduce the risk of surgical wound infection after colorectal surgery? Design: Randomized controlled trial. Setting: Multicentre trial that included 14 hospitals in Spain. Patients: 300 patients aged 18-80 years who underwent elective colorectal resection. Patients who had surgery performed laparoscopically or who had minor colon surgery were excluded. Intervention: Patients were randomly allocated to either 30% or 80% fraction of inspired oxygen (FiO2) intraoperatively and for 6 hours postoperatively. Anesthetic treatment and antibiotic administration were standardized. Main Outcome Measure: Surgical site infection (SSI) as defined by the Center for Disease Control. Results: SSI occurred in 35 of 143 patients (24.4%) who were administered 30% Fio2 and in 22 of 148 patients (14.9%) who were administered 80% FiO2 (p = 0.04). The risk of SSI was 39% lower in the 80% group (relative risk [RR], 0.61; 95% confidence interval [CI], 0.38-0.98) versus the 30% FiO2 group. Conclusions: Patients receiving supplemental oxygen have a significant reduction in risk of surgical site infection.
AB - Objective: Does supplemental perioperative oxygen reduce the risk of surgical wound infection after colorectal surgery? Design: Randomized controlled trial. Setting: Multicentre trial that included 14 hospitals in Spain. Patients: 300 patients aged 18-80 years who underwent elective colorectal resection. Patients who had surgery performed laparoscopically or who had minor colon surgery were excluded. Intervention: Patients were randomly allocated to either 30% or 80% fraction of inspired oxygen (FiO2) intraoperatively and for 6 hours postoperatively. Anesthetic treatment and antibiotic administration were standardized. Main Outcome Measure: Surgical site infection (SSI) as defined by the Center for Disease Control. Results: SSI occurred in 35 of 143 patients (24.4%) who were administered 30% Fio2 and in 22 of 148 patients (14.9%) who were administered 80% FiO2 (p = 0.04). The risk of SSI was 39% lower in the 80% group (relative risk [RR], 0.61; 95% confidence interval [CI], 0.38-0.98) versus the 30% FiO2 group. Conclusions: Patients receiving supplemental oxygen have a significant reduction in risk of surgical site infection.
UR - http://www.scopus.com/inward/record.url?scp=34250880764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250880764&partnerID=8YFLogxK
M3 - Article
VL - 50
SP - 214
EP - 216
JO - Canadian Journal of Surgery
JF - Canadian Journal of Surgery
SN - 0008-428X
IS - 3
ER -