Canadian association of general surgeons and American college of surgeons evidence based reviews in surgery. 21. the risk of surgical site infection is reduced with perioperative oxygen

Karen Brasel, Donna McRitchie, Patch Dellinger, J. S.T. Barkun, K. Brasel, T. Cogbill, S. Cutter, G. W.N. Fitzgerald, H. J.A. Henteleff, A. W. Kirkpatrick, S. Latosinsky, A. Macleon, H. M. MacRae, T. M. Mastracci, R. S. McLeod, L. A. Neumayer, S. Smith, M. C. Taylor, M. E. McKenzie

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Objective: Does supplemental perioperative oxygen reduce the risk of surgical wound infection after colorectal surgery? Design: Randomized controlled trial. Setting: Multicentre trial that included 14 hospitals in Spain. Patients: 300 patients aged 18-80 years who underwent elective colorectal resection. Patients who had surgery performed laparoscopically or who had minor colon surgery were excluded. Intervention: Patients were randomly allocated to either 30% or 80% fraction of inspired oxygen (FiO2) intraoperatively and for 6 hours postoperatively. Anesthetic treatment and antibiotic administration were standardized. Main Outcome Measure: Surgical site infection (SSI) as defined by the Center for Disease Control. Results: SSI occurred in 35 of 143 patients (24.4%) who were administered 30% Fio2 and in 22 of 148 patients (14.9%) who were administered 80% FiO2 (p = 0.04). The risk of SSI was 39% lower in the 80% group (relative risk [RR], 0.61; 95% confidence interval [CI], 0.38-0.98) versus the 30% FiO2 group. Conclusions: Patients receiving supplemental oxygen have a significant reduction in risk of surgical site infection.

Original languageEnglish (US)
Pages (from-to)214-216
Number of pages3
JournalCanadian Journal of Surgery
Volume50
Issue number3
StatePublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Brasel, K., McRitchie, D., Dellinger, P., Barkun, J. S. T., Brasel, K., Cogbill, T., Cutter, S., Fitzgerald, G. W. N., Henteleff, H. J. A., Kirkpatrick, A. W., Latosinsky, S., Macleon, A., MacRae, H. M., Mastracci, T. M., McLeod, R. S., Neumayer, L. A., Smith, S., Taylor, M. C., & McKenzie, M. E. (2007). Canadian association of general surgeons and American college of surgeons evidence based reviews in surgery. 21. the risk of surgical site infection is reduced with perioperative oxygen. Canadian Journal of Surgery, 50(3), 214-216.