Canaries in the coal mine: A cross-species analysis of the plurality of obesity epidemics

Yann C Klimentidis, T. Mark Beasley, Hui Yi Lin, Giulianna Murati, Gregory E. Glass, Marcus Guyton, Wendy Newton, Matthew Jorgensen, Steven B. Heymsfield, Joseph Kemnitz, Lynn Fairbanks, David B. Allison

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

A dramatic rise in obesity has occurred among humans within the last several decades. Little is known about whether similar increases in obesity have occurred in animals inhabiting human-influenced environments. We examined samples collectively consisting of over 20 000 animals from 24 populations (12 divided separately into males and females) of animals representing eight species living with or around humans in industrialized societies. In all populations, the estimated coefficient for the trend of body weight over time was positive (i.e. increasing). The probability of all trends being in the same direction by chance is 1.2 × 10-7. Surprisingly, we find that over the past several decades, average mid-life body weights have risen among primates and rodents living in research colonies, as well as among feral rodents and domestic dogs and cats. The consistency of these findings among animals living in varying environments, suggests the intriguing possibility that the aetiology of increasing body weight may involve several as-of-yet unidentified and/or poorly understood factors (e.g. viral pathogens, epigenetic factors). This finding may eventually enhance the discovery and fuller elucidation of other factors that have contributed to the recent rise in obesity rates.

Original languageEnglish (US)
Pages (from-to)1626-1632
Number of pages7
JournalProceedings of the Royal Society B: Biological Sciences
Volume278
Issue number1712
DOIs
StatePublished - Jun 7 2011
Externally publishedYes

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Canaries
canaries
obesity
Coal
Coal mines
coal
coal mine
Animals
Obesity
body weight
animal
Body Weight
rodents
rodent
Rodentia
animals
epigenetics
etiology
Primates
Pathogens

Keywords

  • Animals
  • Epigenetic
  • Obesity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Canaries in the coal mine : A cross-species analysis of the plurality of obesity epidemics. / Klimentidis, Yann C; Mark Beasley, T.; Lin, Hui Yi; Murati, Giulianna; Glass, Gregory E.; Guyton, Marcus; Newton, Wendy; Jorgensen, Matthew; Heymsfield, Steven B.; Kemnitz, Joseph; Fairbanks, Lynn; Allison, David B.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 278, No. 1712, 07.06.2011, p. 1626-1632.

Research output: Contribution to journalArticle

Klimentidis, YC, Mark Beasley, T, Lin, HY, Murati, G, Glass, GE, Guyton, M, Newton, W, Jorgensen, M, Heymsfield, SB, Kemnitz, J, Fairbanks, L & Allison, DB 2011, 'Canaries in the coal mine: A cross-species analysis of the plurality of obesity epidemics', Proceedings of the Royal Society B: Biological Sciences, vol. 278, no. 1712, pp. 1626-1632. https://doi.org/10.1098/rspb.2010.1890
Klimentidis, Yann C ; Mark Beasley, T. ; Lin, Hui Yi ; Murati, Giulianna ; Glass, Gregory E. ; Guyton, Marcus ; Newton, Wendy ; Jorgensen, Matthew ; Heymsfield, Steven B. ; Kemnitz, Joseph ; Fairbanks, Lynn ; Allison, David B. / Canaries in the coal mine : A cross-species analysis of the plurality of obesity epidemics. In: Proceedings of the Royal Society B: Biological Sciences. 2011 ; Vol. 278, No. 1712. pp. 1626-1632.
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