Cancer prevention by retinoids: Role of immunological modification

Ronald Ross Watson, Satoru Moriguchi

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

High retinoid intakes have be associated with decreased risk of cancer. In addition retinoids are immunomodulating compounds. A mechanism to help explain their anticancer action may be immunosuppression during vitamin A deficiency or immunoenhancement extremely high intakes. Some conditions such as Schistosomiasis are associated with increased cancer risk, immunosuppressions, and low vitamin A levels in serum. In vitro, retinol suppressed T-lymphocyte functions. However, high dietary vitamin A enhanced macrophage functions, which may help explain greater cancer resistance.

Original languageEnglish (US)
Pages (from-to)663-675
Number of pages13
JournalNutrition Research
Volume5
Issue number6
DOIs
StatePublished - Jun 1985

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Keywords

  • Schistosomiasis
  • cancer
  • immunity
  • retinol
  • vitamin A

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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