High retinoid intakes have be associated with decreased risk of cancer. In addition retinoids are immunomodulating compounds. A mechanism to help explain their anticancer action may be immunosuppression during vitamin A deficiency or immunoenhancement extremely high intakes. Some conditions such as Schistosomiasis are associated with increased cancer risk, immunosuppressions, and low vitamin A levels in serum. In vitro, retinol suppressed T-lymphocyte functions. However, high dietary vitamin A enhanced macrophage functions, which may help explain greater cancer resistance.
- vitamin A
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics