Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra

Edward D. French, Kathryn Dillon, Xiaofang Wu

Research output: Contribution to journalArticlepeer-review

266 Scopus citations

Abstract

Extracellular recordings were used to determine the effects of cannabinoids on the activity of dopamine neurons within the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC). Systemic administration of the natural psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) and the synthetic cannabimimetic aminoalkylindole WIN 55,212-2 produced dose-dependent increases in firing rate and burst firing in both neuronal populations. These effects appear to be specific as the non-psychoactive cannabidiol and the inactive enantiomer WIN 55,212-3 failed to alter either parameter of neuronal excitability. Furthermore, dopamine neurons in the VTA were more sensitive than those in the SNC to the stimulatory actions of Δ9-THC. These results may provide a mechanism by which psychoactive cannabinoids increase extracellular dopamine levels in mesolimbic and striatal tissues, and thereby contribute to the reinforcing effects of marijuana.

Original languageEnglish (US)
Pages (from-to)649-652
Number of pages4
JournalNeuroReport
Volume8
Issue number3
DOIs
StatePublished - 1997

Keywords

  • cannabinoids
  • electrophysiology
  • marijuana
  • substantia nigra
  • ventral tegmental area

ASJC Scopus subject areas

  • Neuroscience(all)

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