Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells

Cong Zhao, Kui Song, Jeng Hun Lee, Shin Young Jeong, Lixie Hu, Xingsu Yu, Huifang Su, Zhenfeng Zhang, Yitshak Zohar, Yi Kuen Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

To increase the purity of isolated circulating tumor cells (CTCs) in microfiltration chips, the depletion of leucocytes in human blood was systematically studied as a function of two dimensionless parameters, Capillary number Ca and the normalized leucocyte diameter. An optimized Ca∗ of 0.038 was identified to differentiate the capturing of cancer cells and leucocytes. Such Ca effect can be applied as a guideline for designing an optimized microfiltration system with both high capture efficiency and purity for isolating CTCs from human blood.

Original languageEnglish (US)
Title of host publication2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages346-349
Number of pages4
ISBN (Electronic)9781509019472
DOIs
StatePublished - Nov 28 2016
Event11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016 - Sendai, Japan
Duration: Apr 17 2016Apr 20 2016

Other

Other11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016
CountryJapan
CitySendai
Period4/17/164/20/16

Fingerprint

Microfiltration
Tumors
Blood
Cells

Keywords

  • Capillary number
  • circulating tumor cells
  • CTCs
  • leucocyte depletion
  • microfiltration

ASJC Scopus subject areas

  • Industrial and Manufacturing Engineering
  • Mechanical Engineering
  • Mechanics of Materials
  • Electronic, Optical and Magnetic Materials

Cite this

Zhao, C., Song, K., Lee, J. H., Jeong, S. Y., Hu, L., Yu, X., ... Lee, Y. K. (2016). Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells. In 2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016 (pp. 346-349). [7758264] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS.2016.7758264

Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells. / Zhao, Cong; Song, Kui; Lee, Jeng Hun; Jeong, Shin Young; Hu, Lixie; Yu, Xingsu; Su, Huifang; Zhang, Zhenfeng; Zohar, Yitshak; Lee, Yi Kuen.

2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 346-349 7758264.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhao, C, Song, K, Lee, JH, Jeong, SY, Hu, L, Yu, X, Su, H, Zhang, Z, Zohar, Y & Lee, YK 2016, Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells. in 2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016., 7758264, Institute of Electrical and Electronics Engineers Inc., pp. 346-349, 11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016, Sendai, Japan, 4/17/16. https://doi.org/10.1109/NEMS.2016.7758264
Zhao C, Song K, Lee JH, Jeong SY, Hu L, Yu X et al. Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells. In 2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 346-349. 7758264 https://doi.org/10.1109/NEMS.2016.7758264
Zhao, Cong ; Song, Kui ; Lee, Jeng Hun ; Jeong, Shin Young ; Hu, Lixie ; Yu, Xingsu ; Su, Huifang ; Zhang, Zhenfeng ; Zohar, Yitshak ; Lee, Yi Kuen. / Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells. 2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 346-349
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abstract = "To increase the purity of isolated circulating tumor cells (CTCs) in microfiltration chips, the depletion of leucocytes in human blood was systematically studied as a function of two dimensionless parameters, Capillary number Ca and the normalized leucocyte diameter. An optimized Ca∗ of 0.038 was identified to differentiate the capturing of cancer cells and leucocytes. Such Ca effect can be applied as a guideline for designing an optimized microfiltration system with both high capture efficiency and purity for isolating CTCs from human blood.",
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