Carboplatin therapy in advanced endometrial cancer

Jacob B. Green, Stephanie Green, David S. Alberts, Robert O’Toole, Earl A. Surwit, Judith W. Noltimier

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

A phase II study of the effectiveness and toxicity of carboplatin in the treatment of metastatic or locally advanced endometrial cancer was carried out by the Southwest Oncology Group. Thirty-two patients were registered in the study and 23 were fully evaluable for response and toxicity. Carboplatin was administered in a dose of 400 mg/m2 at 28-day intervals without concomitant hydration if blood counts had recovered sufficiently. There were seven responses (two complete and five partial responses) among the 23 evaluable patients, for an overall response rate of 30%. Four (two of two complete responders and two of five partial responders) of the seven responding patients remain alive at 839+ to 987+ days from the start of therapy. The two complete responders and one of the partial responders had small-volume disease, which may have contributed to their prolonged survival. Myelosuppression was the most prominent toxicity encountered. Seventeen of 27 patients evaluable for toxicity developed platelet counts of less than 75 × 103/µL during therapy, but no hemorrhagic complications were encountered. Leukopenia was less prominent, with only nine of 27 patients developing white blood cell counts of less than 3.0 × 103/µL. No important nephrotoxicity or neurotoxicity was observed. Emesis occurred in ten of 27 patients but was not dose-limiting. No unexpected toxicities were encountered. Carboplatin appears to be an active agent in the treatment of endometrial carcinoma.

Original languageEnglish (US)
Pages (from-to)696-700
Number of pages5
JournalObstetrics and gynecology
Volume75
Issue number4
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Green, J. B., Green, S., Alberts, D. S., O’Toole, R., Surwit, E. A., & Noltimier, J. W. (1990). Carboplatin therapy in advanced endometrial cancer. Obstetrics and gynecology, 75(4), 696-700.